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How to get fromOhio to Knoxvilleby plane, bus, car, bus (Greyhound), or bus (Flixbus)

Find Transport to Knoxville

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There are 8 ways to get from Ohio to Knoxville by plane, bus, car, bus (Greyhound), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Glenn Columbus International Airport

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Mcghee Tyson Airport (TYS)plane plane CMH - TYS
    5h 45m
    $217–1,023

  2. Drive  357.4 mi

    cheapest
    1. Drive from Columbus to Knoxvillecar car 357.4 mi
    5h 58m
    $66–95

  3. Bus

    1. Take the bus from Columbus, OH to New York, NYbus bus Cincinnati
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 40m
    $245–270

  4. Fly from Cleveland-Hopkins International Airport

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Mcghee Tyson Airport (TYS)plane plane CLE - TYS
    5h 12m
    $218–1,022

  5. Fly from Covington

    1. Fly from Covington (CVG) to Mcghee Tyson Airport (TYS)plane plane CVG - TYS
    5h 35m
    $209–1,074

  6. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    5h 10m
    $243–1,058

  7. Bus via Farragut

    1. Take the bus from Columbus to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    27h 22m
    $281–408

  8. Bus via Charlie Haun WB Aft Washington PK

    1. Take the bus from Columbus to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    30h 15m
    $194–257

John Glenn Columbus International Airport (CMH) to Mcghee Tyson Airport (TYS) flights

Calendar102Weekly Planes
Duration4h 17mAverage Duration
Ticket$161Cheapest Price
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Comparing Your Travel Options

Map of how to get from Ohio to Knoxville.ExpandLaunch map view
  • Distance: 321.2 mi
  • Duration: 5h 45m

What companies run services between Ohio, USA and Knoxville, TN, USA?

American Airlines, Delta, and two other airlines fly from John Glenn Columbus International Airport (CMH) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Columbus, OH to Knoxville via New York, NY and Knoxville, TN in around 22h 40m.

Airlines
Bus operators

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