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How to get fromOhio to Mayo Clinicby plane, bus (Flixbus), car, or bus

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There are 9 ways to get from Ohio to Mayo Clinic by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly John Glenn Columbus International Airport to Rochester

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Rochester (RST)plane plane CMH - RST
    6h 54m
    $88–503

  2. Bus

    1. Take the bus from Columbus to Milwaukee Intermodal Stationbus bus FlixBus 2511
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    16h 48m
    $143–219

  3. Drive 656.7 mi

    1. Drive from Columbus to Mayo Cliniccar car 656.7 mi
    11h 57m
    $120–174

  4. Fly Covington to Rochester

    1. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 57m
    $95–534

  5. Fly Cleveland-Hopkins International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 21m
    $604–1,054

  6. Fly John Glenn Columbus International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from John Glenn Columbus International Airport (CMH) to Minneapolis–Saint Paul International Airport (MSP)plane plane CMH - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 41m
    $464–1,055

  7. Fly Covington to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 54m
    $856–1,556

  8. Bus to Detroit, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Minneapolis–Saint Paul International Airport (MSP)plane plane DTW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 59m
    $555–1,297

  9. Bus via Chicago

    1. Take the bus from Columbus - Mound St to Chicagobus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    17h 53m
    $108–207

John Glenn Columbus International Airport (CMH) to Rochester (RST) flights

Calendar49Weekly Planes
Duration4h 53mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

Map of how to get from Ohio to Mayo Clinic.ExpandLaunch map view
  • Distance: 584.2 mi
  • Duration: 6h 54m

What companies run services between Ohio, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from John Glenn Columbus International Airport (CMH) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Columbus to Mayo Clinic via Milwaukee Intermodal Station, Milwaukee, and Rochester in around 16h 48m.

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