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How to get fromOhio to Saint Charlesby plane, bus, taxi, bus (Greyhound), or car

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There are 7 ways to get from Ohio to Saint Charles by plane, bus, taxi, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Glenn Columbus International Airport, line 34 bus, taxi

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    3. Take the taxi from 4375 Rider Trail North Sb to Saint Charlestaxi taxi
    4h 29m
    $822–927

  2. Drive  430.4 mi

    cheapest
    1. Drive from Columbus to Saint Charlescar car 430.4 mi
    7h 17m
    $79–114

  3. Bus (Greyhound)

    1. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    11h 1m
    $86–127

  4. Fly from Cleveland-Hopkins International Airport

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    4h 19m
    $512–926

  5. Fly from Covington

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    6h 43m
    $624–978

  6. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    6h 8m

  7. Bus to Pittsburgh International Airport, fly

    1. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    6h 48m
    $131–641

John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) flights

Calendar22Weekly Planes
Duration2h 45mAverage Duration
Ticket$93Cheapest Price
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Comparing Your Travel Options

Map of how to get from Ohio to Saint Charles.ExpandLaunch map view
  • Distance: 441 mi
  • Duration: 4h 29m

What companies run services between Ohio, USA and Saint Charles, MO, USA?

Greyhound USA operates a bus from Columbus to St Louis Bus Station 3 times a day. Tickets cost $65–110 and the journey takes 9h 5m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 4 hours.

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