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How to get fromOhio to Saint Charlesby plane, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

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There are 9 ways to get from Ohio to Saint Charles by plane, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Glenn Columbus International Airport, line 34 bus

    best
    1. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    4h 19m
    $106–657

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from Columbus to Dayton Trotwood Bus Stationbus bus
    2. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    10h 35m
    $67–133

  3. Drive 430.4 mi

    1. Drive from Columbus to Saint Charlescar car 430.4 mi
    7h 17m
    $79–114

  4. Fly from Cleveland-Hopkins International Airport

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    4h 9m
    $496–906

  5. Fly from Covington

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    6h 29m
    $128–708

  6. Fly from Dayton

    1. Fly from Dayton (DAY) to Lambert–St. Louis International Airport (STL)plane plane DAY - STL
    6h 41m
    $136–756

  7. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    5h 54m
    $437–999

  8. Bus to Pittsburgh International Airport, fly

    1. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    6h 38m
    $125–674

  9. Bus (Greyhound)

    1. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    10h 53m
    $69–126

Ohio to Saint Charles by bus and train

Calendar10Weekly Services
Duration10h 35mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Ohio to Saint Charles.ExpandLaunch map view
  • Distance: 435.4 mi
  • Duration: 4h 19m

What companies run services between Ohio, USA and Saint Charles, MO, USA?

You can take a bus from Columbus to 4375 Rider Trail North Sb via Dayton Trotwood Bus Station, Indianapolis Union Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 10h 35m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 3 hours.

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