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How to get fromOld Lyme to Hyannisby train, bus, train (Amtrak), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Old Lyme to Hyannis by train, bus, train (Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus via Boston

    best
    1. Take the train from New London to Bostontrain train Northeast Regional
    2. Take the bus from South Station Transp. Ctr to Hyannis Transportation Centerbus bus Hyannis - South Shore to Logan Airport
    5h 44m
    $59–112

  2. Drive 136.6 mi

    cheapest
    1. Drive from Old Lyme to Hyanniscar car 136.6 mi
    2h 47m
    $25–36

  3. Train

    1. Take the train from Old Saybrook Amtrak Station to Bostontrain train Northeast Regional
    2. Take the train from South Station to Hyannistrain train CapeFLYER
    6h 56m
    $45–103

  4. Train, bus

    1. Take the train from New London to Bostontrain train Northeast Regional
    2. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus Boston
    6h 2m
    $47–112

  5. Train, bus via Providence

    1. Take the train from New London to Providencetrain train Northeast Regional
    2. Take the bus from Providence to Hyannisbus bus Bz 0918 / ...
    6h 28m
    $38–94

  6. Bus

    1. Take the bus from Old Saybrook Trans Cntr to Asylum St @ Union Plbus bus 921
    2. Take the bus from Hartford Union Station to Bostonbus bus
    3. Take the bus from South Station Transp. Ctr to Hyannis Transportation Centerbus bus
    6h 55m
    $45–81

Old Lyme to Hyannis by bus and train

Calendar30Weekly Services
Duration5h 44mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Old Lyme to Hyannis.ExpandLaunch map view
  • Distance: 199 mi
  • Duration: 5h 44m

What companies run services between Old Lyme, CT, USA and Hyannis, MA, USA?

You can take a bus from Lyme St & Library Ln to Hyannis via Stage Rd & Route 1, Old Saybrook Amtrak Station, Boston, and South Station in around 6h 56m. Alternatively, you can take a bus from Lyme St & Library Ln to Hyannis Transportation Center via Old Saybrook Train Station Bus Shelter, Old Saybrook Trans Cntr, Asylum St @ Union Pl, Hartford Union Station, Boston, and South Station Transp. Ctr in around 6h 55m.

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