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How to get fromOpelousas to Chicagoby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Opelousas to Chicago by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lafayette Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Lafayette Regional Airport (LFT) to Chicago Midway International Airport (MDW)plane plane LFT - MDW
    6h 10m
    $133–438

  2. Fly Lafayette Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Lafayette Regional Airport (LFT) to Chicago O'Hare International Airport (ORD)plane plane LFT - ORD
    6h 13m
    $93–398

  3. Bus, train

    1. Take the bus from Opelousas to New Orleans Bus Stationbus bus Greyhound 2221 / ...
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train City of New Orleans
    25h 21m
    $339–718

  4. Bus

    1. Take the bus from Opelousas to Baton Rouge Bus Stationbus bus
    2. Take the bus from Baton Rouge Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    26h 16m
    $185–341

  5. Drive 921 mi

    1. Drive from Opelousas to Chicagocar car 921 mi
    16h 47m
    $169–243

  6. Bus to Alexandria International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Opelousas to Boyce, LAbus bus
    2. Fly from Alexandria International Airport (AEX) to Chicago Midway International Airport (MDW)plane plane AEX - MDW
    8h 15m
    $165–484

Lafayette Regional Airport (LFT) to Chicago Midway International Airport (MDW) flights

Calendar20Weekly Planes
Duration5h 24mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Opelousas to Chicago.ExpandLaunch map view
  • Distance: 870.1 mi
  • Duration: 6h 10m

What companies run services between Opelousas, LA, USA and Chicago, IL, USA?

Delta, American Airlines, and Frontier Airlines fly from Lafayette Regional Airport (LFT) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a vehicle from Opelousas to Chicago Bus Station via Opelousas, Baton Rouge Bus Station, and St Louis Bus Station in around 26h 16m.

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