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How to get fromOpelousas to Mobileby bus, train, car, plane, bus (Greyhound, Flixbus), or train (Amtrak)

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There are 8 ways to get from Opelousas to Mobile by bus, train, car, plane, bus (Greyhound, Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Lafayette to Mobilebus bus Houston
    5h 13m
    $76–103

  2. Drive 258.1 mi

    cheapest
    1. Drive from Opelousas to Mobilecar car 258.1 mi
    4h 22m
    $48–68

  3. Bus, train via Baton Rouge

    1. Take the bus from Opelousas to Baton Rouge Bus Stationbus bus
    2. Take the bus from Baton Rouge Bus Station to New Orleans Bus Stationbus bus
    3. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    7h 19m
    $62–145

  4. Fly to Mobile Regional Airport

    1. Fly from Lafayette Regional Airport (LFT) to Mobile Regional Airport (MOB)plane plane LFT - MOB
    7h 35m
    $76–383

  5. Bus via Baton Rouge

    1. Take the bus from Opelousas to Baton Rouge Bus Stationbus bus Greyhound 2221 / ...
    2. Take the bus from Baton Rouge Bus Station to Mobile Bus Stationbus bus Greyhound US0602 / ...
    6h 48m
    $50–91

  6. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to New Orleans Union Passenger Terminaltrain train Sunset Limited
    2. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train Amtrak Mardi Gras Service / ...
    8h 32m
    $86–198

  7. Bus, train

    1. Take the bus from Opelousas to New Orleans Bus Stationbus bus Greyhound 2221 / ...
    2. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train Amtrak Mardi Gras Service / ...
    8h 34m
    $69–158

  8. Fly to Pensacola International Airport, bus

    1. Fly from Lafayette Regional Airport (LFT) to Pensacola International Airport (PNS)plane plane LFT - PNS
    2. Take the bus from Pensacola Airport to Mobile Bus Stationbus bus
    8h 3m
    $85–381

Lafayette Regional Airport (LFT) to Mobile Regional Airport (MOB) flights

Calendar63Weekly Planes
Duration5h 15mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from Opelousas to Mobile.ExpandLaunch map view
  • Distance: 319.8 mi
  • Duration: 5h 13m

What companies run services between Opelousas, LA, USA and Mobile, AL, USA?

Omnibus Express operates a bus from Lafayette to Mobile once daily. Tickets cost $65–90 and the journey takes 4h 49m. Alternatively, United Airlines, Delta, and American Airlines fly from Lafayette Regional Airport (LFT) to Mobile Regional Airport (MOB) every 3 hours.

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