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How to get fromOpelousas to San Antonioby bus (Flixbus), train (Amtrak), car, plane, bus (Greyhound), or bus

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There are 7 ways to get from Opelousas to San Antonio by bus (Flixbus), train (Amtrak), car, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Lafayette to San Antonio Bus Stationbus bus FlixBus 2212
    7h 43m
    $76–123

  2. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to San Antonio Stationtrain train Sunset Limited
    12h 5m
    $141–303

  3. Drive 415 mi

    1. Drive from Opelousas to San Antoniocar car 415 mi
    7h 5m
    $76–110

  4. Fly from Lafayette Regional Airport

    1. Fly from Lafayette Regional Airport (LFT) to San Antonio International Airport (SAT)plane plane LFT - SAT
    4h 49m
    $83–455

  5. Bus via Houston

    1. Take the bus from Lafayette Transit System to Houston Bus Stationbus bus Greyhound US0602 / ...
    2. Take the bus from Hyatt Regency Galleria Houston to San Antoniobus bus Houston
    9h 42m
    $173–231

  6. Bus to Alexandria International Airport, fly

    1. Take the bus from Opelousas to Boyce, LAbus bus
    2. Fly from Alexandria International Airport (AEX) to San Antonio International Airport (SAT)plane plane AEX - SAT
    6h 55m
    $115–491

  7. Bus to Lake Charles Regional Airport, fly

    1. Take the bus from Lafayette to Lake Charlesbus bus
    2. Fly from Lake Charles Regional Airport (LCH) to San Antonio International Airport (SAT)plane plane LCH - SAT
    6h 30m
    $129–508

Lafayette Regional Airport (LFT) to San Antonio International Airport (SAT) flights

Calendar80Weekly Planes
Duration4h 55mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Opelousas to San Antonio.ExpandLaunch map view
  • Distance: 431.1 mi
  • Duration: 7h 43m

What companies run services between Opelousas, LA, USA and San Antonio, TX, USA?

Flixbus USA operates a bus from Lafayette to San Antonio Bus Station 5 times a week. Tickets cost $65–110 and the journey takes 7h 20m. Alternatively, Amtrak operates a train from Lafayette Amtrak Station to San Antonio Station 3 times a week. Tickets cost $130–290 and the journey takes 11h 41m.

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