Rome2Rio

How to get fromOrange County to Knoxvilleby plane, train, bus, bus (Greyhound), or car

Find Transport to Knoxville

See all options

There are 6 ways to get from Orange County to Knoxville by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS)plane plane SNA - TYS
    6h 27m
    $384–1,404

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to Los Angelestrain train
    2. Fly from Los Angeles International Airport (LAX) to Mcghee Tyson Airport (TYS)plane plane LAX - TYS
    9h 29m
    $343–1,306

  3. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 6h
    $1,085–2,322

  4. Bus

    1. Take the bus from Santa Ana to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 9h
    $623–1,116

  5. Drive 2,163.8 mi

    1. Drive from Orange County to Knoxvillecar car 2,163.8 mi
    34h 18m
    $395–571

  6. Train, bus via Farragut

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus
    3d 7h
    $1,127–2,407

John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) flights

Calendar56Weekly Planes
Duration6h 49mAverage Duration
Ticket$307Cheapest Price
See schedules

Questions & Answers

Map of how to get from Orange County to Knoxville.ExpandLaunch map view
  • Distance: 1,937.7 mi
  • Duration: 6h 27m

What companies run services between Orange County, CA, USA and Knoxville, TN, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Santa Ana to Knoxville via Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 9h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers