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How to get fromOrange Park to Florida Keysby train, bus, bus (Flixbus, Greyhound), car, plane, or shuttle

Find Transport to Florida Keys

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There are 8 ways to get from Orange Park to Florida Keys by train, bus, bus (Flixbus, Greyhound), car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Jacksonville to West Palm Beach Amtrak Stationtrain train
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    16h 18m
    $155–302

  2. Bus

    cheapest
    1. Take the bus from Jacksonville to Miami Airport Stationbus bus FlixBus 2431 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    16h 56m
    $83–152

  3. Drive  484.6 mi

    1. Drive from Orange Park to Florida Keyscar car 484.6 mi
    8h 41m
    $89–128

  4. Fly Jacksonville to Key West International Airport

    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    9h 48m
    $125–370

  5. Bus, shuttle

    1. Take the bus from Jacksonville to Miami Golden Gladesbus bus FlixBus 2431
    2. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus To the Keys
    17h 2m
    $216–287

  6. Drive to Orlando Sanford, fly to Key West International Airport

    1. Drive from Orange Park to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    6h 21m
    $134–396

  7. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 43m
    $200–500

  8. Fly Jacksonville to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 14m
    $285–400

Orange Park to Florida Keys by bus and foot

Calendar19Weekly Services
Duration16h 56mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Orange Park to Florida Keys.ExpandLaunch map view
  • Distance: 571.5 mi
  • Duration: 16h 18m

What companies run services between Orange Park, FL, USA and Florida Keys, FL, USA?

You can take a bus from Park Ave & Mc Intosh Ave to Florida Keys via JRTC - Express Select, Jacksonville, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 16h 56m. Alternatively, Delta and American Airlines fly from Jacksonville (JAX) to Key West International Airport (EYW) every 3 hours.

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