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How to get fromOrangeburg to Durhamby bus (Flixbus, Greyhound), train (Amtrak), car, taxi, plane, bus, train, or bus (Greyhound)

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There are 7 ways to get from Orangeburg to Durham by bus (Flixbus, Greyhound), train (Amtrak), car, taxi, plane, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Charlotte

    best
    1. Take the bus from Orangeburg to Charlotte Bus Stationbus bus FlixBus 2433
    2. Take the bus from Charlotte Bus Station to Durhambus bus FlixBus N2471 / ...
    6h 8m
    $50–84

  2. Drive  239.7 mi

    cheapest
    1. Drive from Orangeburg to Durhamcar car 239.7 mi
    4h 45m
    $44–64

  3. Train (Amtrak)

    1. Take the train from Denmark Amtrak Station to Carytrain train Floridian
    7h 10m
    $207–306

  4. Taxi to Columbia, fly

    1. Take the taxi from Orangeburg to Columbia-Airport-CAEtaxi taxi
    2. Fly from Columbia (CAE) to Raleigh-Durham International Airport (RDU)plane plane CAE - RDU
    5h 25m
    $186–554

  5. Bus, train

    1. Take the bus from Orangeburg to Charlotte Bus Stationbus bus FlixBus 2433
    2. Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain train Piedmont / ...
    6h 40m
    $110–180

  6. Bus

    1. Take the bus from Orangeburg to Camdenbus bus Greyhound US0644S
    2. Take the bus from Camden to Durhambus bus Augusta
    7h 48m
    $64–93

  7. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Orangeburg to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Raleigh-Durham International Airport (RDU)plane plane CLT - RDU
    6h 44m
    $93–476

Columbia (CAE) to Raleigh-Durham International Airport (RDU) flights

Calendar125Weekly Planes
Duration4h 23mAverage Duration
Ticket$58Cheapest Price
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Comparing Your Travel Options

Map of how to get from Orangeburg to Durham.ExpandLaunch map view
  • Distance: 279.8 mi
  • Duration: 6h 8m

What companies run services between Orangeburg, SC, USA and Durham, NC, USA?

You can take a vehicle from Orangeburg to Durham via Orangeburg and Charlotte Bus Station in around 6h 8m. Alternatively, Amtrak operates a train from Denmark Amtrak Station to Cary once daily. Tickets cost $130–210 and the journey takes 5h 20m.

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