There are 6 ways to get from Orangeburg to Fort Myers by taxi, plane, bus (Flixbus), train, bus, car, or bus (Flixbus, Greyhound, Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Columbia, fly
best- Take the taxi from Orangeburg to Columbia-Airport-CAEtaxi
- Fly from Columbia (CAE) to Ft. Myers (RSW)plane CAE - RSW
6h 40m$318–1,153Drive 530 mi
cheapest- Drive from Orangeburg to Fort Myerscar 530 mi
9h 48m$97–140Bus (Flixbus)
- Take the bus from Orangeburg to Orlando Bus Stationbus FlixBus 2433
- Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus FlixBus 2421
13h 43m$103–179Train, bus
- Take the train from Denmark Amtrak Station to Tampatrain Floridian
- Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus FlixBus 2421
15h 48m$243–444Bus to Charleston International Airport, fly
- Take the bus from Orangeburg to Charleston Bus Stationbus
- Fly from Charleston International Airport (CHS) to Ft. Myers (RSW)plane CHS - RSW
8h 17m$110–479Bus via Jacksonville
- Take the bus from Orangeburg to Jacksonvillebus
- Take the bus from Jacksonville to Wildwood Amtrak Stationbus
- Take the bus from Wildwood to Fort Myersbus
15h 58m$149–237
Columbia (CAE) to Ft. Myers (RSW) flights
Questions & Answers
The cheapest way to get from Orangeburg to Fort Myers is to drive which costs $95 - $140 and takes 9h 48m.
The fastest way to get from Orangeburg to Fort Myers is to taxi and fly which takes 6h 40m and costs $310 - $1,200.
No, there is no direct bus from Orangeburg to Fort Myers. However, there are services departing from Orangeburg and arriving at Fort Myers Bus Stop via Orlando Bus Station. The journey, including transfers, takes approximately 13h 43m.
The distance between Orangeburg and Fort Myers is 572 miles. The road distance is 533.1 miles.
The best way to get from Orangeburg to Fort Myers without a car is to bus which takes 13h 43m and costs $100 - $180.
It takes approximately 6h 40m to get from Orangeburg to Fort Myers, including transfers.
Orangeburg to Fort Myers bus services, operated by Flixbus USA, depart from Orangeburg station.
Orangeburg to Fort Myers bus services, operated by Flixbus USA, arrive at Orlando Bus Station.
Yes, the driving distance between Orangeburg to Fort Myers is 533 miles. It takes approximately 9h 48m to drive from Orangeburg to Fort Myers.
Book your Orangeburg to Fort Myers bus tickets online with Omio.
What companies run services between Orangeburg, SC, USA and Fort Myers, FL, USA?
You can take a vehicle from Orangeburg to Fort Myers Bus Stop via Orangeburg and Orlando Bus Station in around 13h 43m.
- Website
- delta.com
Flights from Columbia to Ft. Myers via Atlanta
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Charleston International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $85–440
- Website
- aa.com
Flights from Columbia to Ft. Myers via Charlotte
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Columbia to Ft. Myers via Reagan Washington
- Ave. Duration
- 7h 14m
- When
- Sunday
- Estimated price
- $290–1,300
Flights from Columbia to Ft. Myers via New York La Guardia
- Ave. Duration
- 8h 5m
- When
- Every day
- Estimated price
- $360–1,500
Flights from Charleston International Airport to Ft. Myers via Charlotte
- Ave. Duration
- 3h 59m
- When
- Monday, Tuesday, Thursday, Friday, and Saturday
- Estimated price
- $85–440
- Website
- united.com
Flights from Columbia to Ft. Myers via Newark
- Ave. Duration
- 8h 6m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $360–1,500
Flights from Columbia to Ft. Myers via Chicago O'Hare
- Ave. Duration
- 8h 11m
- When
- Every day
- Estimated price
- $380–1,600
- Website
- flybreeze.com
Flights from Charleston International Airport to Ft. Myers
- Ave. Duration
- 1h 39m
- When
- Wednesday, Saturday, Monday, and Friday
- Estimated price
- $140–950
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Denmark Amtrak Station to Tampa
- Ave. Duration
- 10h 55m
- Frequency
- Once daily
- Estimated price
- $150–320
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Orangeburg to Orlando Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $60–110
- Schedules at
- flixbus.com
Bus from Orlando Bus Station to Fort Myers Bus Stop
- Ave. Duration
- 5h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–60
- Schedules at
- flixbus.com
Bus from Tampa Bus Station to Fort Myers Bus Stop
- Ave. Duration
- 3h 5m
- Frequency
- 3 times a day
- Estimated price
- $21–40
- Schedules at
- flixbus.com
Bus from Orangeburg to Jacksonville
- Ave. Duration
- 4h 40m
- Frequency
- Once daily
- Estimated price
- $40–70
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Orangeburg to Charleston Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $10–21
- Website
- https://www.greyhound.com/
Bus from Orangeburg to Jacksonville
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Jacksonville to Wildwood Amtrak Station
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $45–70
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-923-1799
- [email protected]
- Website
- omnibusexpress.com
Bus from Wildwood to Fort Myers
- Ave. Duration
- 4h 29m
- Frequency
- Once daily
- Estimated price
- $60–80
- Schedules at
- omnibusexpress.com
- Ave. Duration
- 43 min
- Estimated price
- $120–150
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 3351+ hotels available in Fort Myers.








