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How to get fromOrangeburg to Knoxvilleby taxi, plane, bus, shuttle, or car

Find Transport to Knoxville

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There are 5 ways to get from Orangeburg to Knoxville by taxi, plane, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Columbia, fly

    best
    1. Take the taxi from Orangeburg to Columbia-Airport-CAEtaxi taxi
    2. Fly from Columbia (CAE) to Mcghee Tyson Airport (TYS)plane plane CAE - TYS
    4h 2m
    $360–1,518

  2. Drive 301 mi

    cheapest
    1. Drive from Orangeburg to Knoxvillecar car 301 mi
    5h 10m
    $55–80

  3. Bus, shuttle, drive

    1. Take the bus from Orangeburg to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    13h 15m
    $362–417

  4. Drive to Augusta Regional Airport At Bush Field, fly

    1. Drive from Orangeburg to Augusta Regional Airport At Bush Field (AGS)car car
    2. Fly from Augusta Regional Airport At Bush Field (AGS) to Mcghee Tyson Airport (TYS)plane plane AGS - TYS
    5h 5m
    $149–640

  5. Bus, taxi, shuttle, drive

    1. Take the bus from Orangeburg to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take the taxi from ASU Peacock Hall Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Chilhowee at Holstoncar car
    13h 30m
    $397–482

Columbia (CAE) to Mcghee Tyson Airport (TYS) flights

Calendar139Weekly Planes
Duration4h 34mAverage Duration
Ticket$188Cheapest Price
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Questions & Answers

Map of how to get from Orangeburg to Knoxville.ExpandLaunch map view
  • Distance: 259.8 mi
  • Duration: 4h 2m

What companies run services between Orangeburg, SC, USA and Knoxville, TN, USA?

There is no direct connection from Orangeburg to Knoxville. However, you can take the taxi to Columbia-Airport-CAE airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a vehicle from Orangeburg to Knoxville via Orangeburg, Charlotte Bus Station, Trade St & Graham St, Transit Center- Bay A, Transit Center- Bay V, Charlotte Douglas Airport, Charlotte Airport, ASU Peacock Hall Boone, Boone, Black Bear Resort, and Hot Springs in around 13h 15m.

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