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How to get fromOrchard Park to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), or car

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There are 7 ways to get from Orchard Park to Chicago by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 72 bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from West Quaker Road & Linwood Avenue to Lower Terrace & Adams Markbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4h 55m
    $105–465

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    13h 16m
    $87–177

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    10h 52m
    $209–396

  4. Drive 526.7 mi

    1. Drive from Orchard Park to Chicagocar car 526.7 mi
    8h 57m
    $97–139

  5. Line 72 bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from West Quaker Road & Linwood Avenue to Lower Terrace & Adams Markbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    5h 18m
    $155–405

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 53m
    $113–493

  7. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 23m
    $98–423

Orchard Park to Chicago by bus and foot (Greyhound)

Calendar10Weekly Services
Duration13h 16mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Orchard Park to Chicago.ExpandLaunch map view
  • Distance: 502.2 mi
  • Duration: 4h 55m

What companies run services between Orchard Park, Erie County, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $170–350 and the journey takes 10h 33m. Alternatively, you can take a bus from West Quaker Road & Linwood Avenue to Chicago Bus Station via Lower Terrace & Adams Mark, Buffalo, and Cleveland Bus Station in around 13h 16m.

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