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How to get fromOrland Park to Mayo Clinicby train, plane, bus, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Orland Park to Mayo Clinic by train, plane, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Orland Park 143rd to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 33m
    $48–341

  2. Train, bus via Milwaukee

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    10h 7m
    $102–166

  3. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    11h 54m
    $163–316

  4. Drive 353.9 mi

    1. Drive from Orland Park to Mayo Cliniccar car 353.9 mi
    6h 6m
    $65–94

  5. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 29m
    $129–535

  6. Train to Chicago O'Hare International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Orland Park 143rd to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 16m
    $279–513

  7. Bus

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    10h 56m
    $80–136

  8. Bus via Chicago

    1. Take the bus from Chicago Bus Station to Madisonbus bus FlixBus 2548 / ...
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    11h 12m
    $81–131

Orland Park to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration10h 7mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Orland Park to Mayo Clinic.ExpandLaunch map view
  • Distance: 318.7 mi
  • Duration: 5h 33m

What companies run services between Orland Park, IL, USA and Mayo Clinic, MN, USA?

You can take a train from Orland Park 143rd to Mayo Clinic via Chicago Union Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 10h 56m.

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