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How to get fromOrlando Health/Amtrak to Knoxvilleby plane, train, bus, bus (Flixbus), or car

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There are 7 ways to get from Orlando Health/Amtrak to Knoxville by plane, train, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando Sanford to Mcghee Tyson Airport

    best
    1. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    2h 31m
    $228–795

  2. Drive 635.7 mi

    cheapest
    1. Drive from Orlando Health/Amtrak to Knoxvillecar car 635.7 mi
    10h 42m
    $116–168

  3. Train, bus via Farragut

    1. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York to Knoxvillebus bus Nyc
    35h 47m
    $541–991

  4. Bus

    1. Take the bus from Orlando Bus Station to New York City Chinatownbus bus FlixBus N2472
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 18m
    $281–417

  5. Fly Orlando to Mcghee Tyson Airport

    1. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3h 34m
    $159–675

  6. Fly Orlando Sanford to Asheville Regional Airport, drive

    1. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 27m
    $140–450

  7. Train, bus

    1. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    35h 51m
    $496–901

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Orlando Health/Amtrak to Knoxville.ExpandLaunch map view
  • Distance: 546.5 mi
  • Duration: 2h 31m

What companies run services between Orlando Health/Amtrak, FL, USA and Knoxville, TN, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a bus from Sligh Blvd & W Copeland Dr to Knoxville Station Hall of Fame via N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 40h 18m.

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