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How to get fromOrlando Health/Amtrak to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

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There are 6 ways to get from Orlando Health/Amtrak to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Lambert–St. Louis International Airport

    best
    1. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    4h 45m
    $187–378

  2. Bus

    cheapest
    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    21h 40m
    $154–304

  3. Train (Amtrak)

    1. Take the train from Orlando to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    44h 41m
    $644–1,315

  4. Drive 989.4 mi

    1. Drive from Orlando Health/Amtrak to St. Louiscar car 989.4 mi
    16h 19m
    $181–261

  5. Fly Orlando Sanford to Midamerica St. Louis Airport, train

    1. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    4h 2m
    $169–527

  6. Train to Tampa, fly to Lambert–St. Louis International Airport

    1. Take the train from Orlando to Tampatrain train
    2. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    7h 27m
    $458–2,070

Orlando Health/Amtrak to St. Louis by train and bus

Calendar12Weekly Services
Duration21h 40mAverage Duration
Ticket$154Cheapest Price
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Questions & Answers

Map of how to get from Orlando Health/Amtrak to St. Louis.ExpandLaunch map view
  • Distance: 917.9 mi
  • Duration: 4h 45m

What companies run services between Orlando Health/Amtrak, FL, USA and St. Louis, MO, USA?

Frontier Airlines, Southwest Airlines, and Delta fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a train from Orlando Health/Amtrak to St Louis Bus Station via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Atlanta Bus Station in around 21h 40m.

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