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How to get fromOrlando to Des Moinesby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Des Moines

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There are 5 ways to get from Orlando to Des Moines by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Orlando

    best
    1. Fly from Orlando (MCO) to Des Moines (DSM)plane plane MCO - DSM
    6h 26m
    $179–773

  2. Bus

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    29h 20m
    $224–430

  3. Train, bus

    1. Take the train from Orlando to Chicago Union Stationtrain train Floridian
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    46h 34m
    $610–1,221

  4. Drive 1,319.3 mi

    1. Drive from Orlando to Des Moinescar car 1,319.3 mi
    22h 51m
    $241–348

  5. Fly from Orlando Sanford

    1. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    3h 49m
    $248–894

Orlando to Des Moines by bus

Calendar7Weekly Buses
Duration29h 20mAverage Duration
Ticket$224Cheapest Price
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Questions & Answers

Map of how to get from Orlando to Des Moines.ExpandLaunch map view
  • Distance: 1,163.8 mi
  • Duration: 6h 26m

What companies run services between Orlando, FL, USA and Des Moines, IA, USA?

Delta, Southwest Airlines, and two other airlines fly from Orlando (MCO) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Orlando Bus Station to Des Moines via Atlanta Bus Station and St Louis Bus Station in around 29h 20m.

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