There are 5 ways to get from Orlando to Florida Keys by plane, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Orlando Sanford
best- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
1h 54m$96–323Drive 370.8 mi
cheapest- Drive from Orlando to Key Westcar 370.8 mi
7h 44m$68–98Fly from Orlando
- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
2h 30m$72–652Bus to Tampa, fly
- Take the bus from Orlando Bus Station to Tampa Bus Stationbus
- Fly from Tampa (TPA) to Key West International Airport (EYW)plane TPA - EYW
4h 53m$85–417Amtrak Thruway to Saint Petersburg–Clearwater International Airport, fly
- Take the bus from Orlando, FL to St. Petersburgbus
- Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane PIE - EYW
5h 47m$75–294
Orlando Sanford (SFB) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Orlando to Florida Keys is to drive which costs $65 - $100 and takes 7h 44m.
The fastest way to get from Orlando to Florida Keys is to fly which takes 1h 54m and costs $95 - $330.
The distance between Orlando and Florida Keys is 317 miles. The road distance is 372.9 miles.
It takes approximately 1h 54m to get from Orlando to Florida Keys, including transfers.
Yes, the driving distance between Orlando to Florida Keys is 373 miles. It takes approximately 7h 44m to drive from Orlando to Florida Keys.
There are 866+ hotels available in Florida Keys.
What companies run services between Orlando, FL, USA and Florida Keys, Monroe County, FL, USA?
Allegiant Air flies from Orlando Sanford (SFB) to Key West International Airport (EYW) 3 times a week.
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 20m
- When
- Sunday and Thursday
- Estimated price
- $35–250
Flights from Saint Petersburg–Clearwater International Airport to Key West International Airport
- Ave. Duration
- 1h 4m
- When
- Monday, Friday, Wednesday, Saturday, Thursday, and Sunday
- Estimated price
- $35–240
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $70–650
Flights from Tampa to Key West International Airport
- Ave. Duration
- 1h 18m
- When
- Thursday, Sunday, Monday, Wednesday, Friday, and Tuesday
- Estimated price
- $70–390
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Orlando Bus Station to Tampa Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Estimated price
- $13–22
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Orlando Bus Station to Tampa Bus Station
- Ave. Duration
- 3h 5m
- Frequency
- Twice daily
- Estimated price
- $12–24
- Website
- Greyhound
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Orlando, FL to St. Petersburg
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Amtrak
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