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How to get fromOrlando to Knoxvilleby plane, bus, shuttle, car, train, or taxi

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There are 6 ways to get from Orlando to Knoxville by plane, bus, shuttle, car, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando Sanford to Mcghee Tyson Airport

    best
    1. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    2h 29m
    $256–993

  2. Drive  635.4 mi

    cheapest
    1. Drive from Orlando to Knoxvillecar car 635.4 mi
    10h 41m
    $116–168

  3. Bus, shuttle, drive

    1. Take the bus from Orlando Bus Station to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    19h 29m
    $333–386

  4. Train, bus, taxi, shuttle, drive

    1. Take the train from Orlando to Carytrain train
    2. Take the train from Cary to High Pointtrain train
    3. Take the bus from Forsyth Hospital to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    25h 40m
    $677–935

  5. Fly Orlando to Mcghee Tyson Airport

    1. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3h 15m
    $197–922

  6. Fly Orlando Sanford to Asheville Regional Airport, drive

    1. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 18m
    $138–458

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar12Weekly Planes
Duration1h 37mAverage Duration
Ticket$147Cheapest Price
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Comparing Your Travel Options

Map of how to get from Orlando to Knoxville.ExpandLaunch map view
  • Distance: 545.7 mi
  • Duration: 2h 29m

What companies run services between Orlando, FL, USA and Knoxville, TN, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) twice daily.

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