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How to get fromOrlando to Lexingtonby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Lexington

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There are 6 ways to get from Orlando to Lexington by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia

    best
    1. Fly from Orlando (MCO) to Columbia (CAE)plane plane MCO - CAE
    5h 16m
    $180–887

  2. Drive 412 mi

    cheapest
    1. Drive from Orlando to Lexingtoncar car 412 mi
    7h 51m
    $76–109

  3. Bus

    1. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    12h 35m
    $131–219

  4. Train, bus

    1. Take the train from Orlando to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Sumter Bus Stopbus bus
    3. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Blanding Northbus bus 44
    15h 23m
    $197–364

  5. Fly to Charleston International Airport, drive

    1. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    2. Drive from Charleston-Airport-CHS to Lexingtoncar car
    4h 39m
    $87–282

  6. Train, bus via Fayetteville

    1. Take the train from Orlando to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    16h 56m
    $267–499

Orlando (MCO) to Columbia (CAE) flights

Calendar132Weekly Planes
Duration4h 58mAverage Duration
Ticket$151Cheapest Price
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Questions & Answers

Map of how to get from Orlando to Lexington.ExpandLaunch map view
  • Distance: 406 mi
  • Duration: 5h 16m

What companies run services between Orlando, FL, USA and Lexington, SC, USA?

Delta, American Airlines, and United Airlines fly from Orlando (MCO) to Columbia (CAE) hourly. Alternatively, you can take a bus from Orlando Bus Station to Lexington via Jacksonville, Camden, and Columbia, SC in around 12h 35m.

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