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How to get fromOrlando to Louisvilleby plane, bus (Flixbus, Greyhound, Amtrak), car, or bus

Find Transport to Louisville

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There are 6 ways to get from Orlando to Louisville by plane, bus (Flixbus, Greyhound, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Louisville International Airport

    best
    1. Fly from Orlando (MCO) to Louisville International Airport (SDF)plane plane MCO - SDF
    4h 36m
    $393–805

  2. Bus

    cheapest
    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    17h 10m
    $130–225

  3. Drive  811.5 mi

    1. Drive from Orlando to Louisvillecar car 811.5 mi
    14h 37m
    $149–214

  4. Fly Orlando Sanford to Blue Grass Airport, drive

    1. Fly from Orlando Sanford (SFB) to Blue Grass Airport (LEX)plane plane SFB - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    3h 49m
    $144–482

  5. Fly Orlando Sanford to Louisville International Airport

    1. Fly from Orlando Sanford (SFB) to Louisville International Airport (SDF)plane plane SFB - SDF
    3h 53m
    $182–776

  6. Bus to Tampa, fly to Louisville International Airport

    1. Take the bus from Orlando Bus Station to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Louisville International Airport (SDF)plane plane TPA - SDF
    6h 52m
    $135–727

Orlando to Louisville by bus

Calendar14Weekly Buses
Duration17h 10mAverage Duration
Ticket$130Cheapest Price
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Comparing Your Travel Options

Map of how to get from Orlando to Louisville.ExpandLaunch map view
  • Distance: 743.2 mi
  • Duration: 4h 36m

What companies run services between Orlando, FL, USA and Louisville, KY, USA?

Delta and Southwest Airlines fly from Orlando (MCO) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Orlando Bus Station to Louisville, KY via Atlanta Bus Station and Nashville in around 17h 10m.

Airlines
Bus operators

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