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How to get fromOrlando to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Mayo Clinic

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There are 7 ways to get from Orlando to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Rochester

    best
    1. Fly from Orlando (MCO) to Rochester (RST)plane plane MCO - RST
    7h 47m
    $103–512

  2. Bus

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    33h 29m
    $264–444

  3. Train, bus via Madison

    1. Take the train from Orlando to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    2d
    $1,018–1,577

  4. Drive  1,437.3 mi

    1. Drive from Orlando to Mayo Cliniccar car 1,437.3 mi
    24h 26m
    $246–355

  5. Fly Orlando to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Orlando (MCO) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCO - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 55m
    $202–542

  6. Bus to Tampa, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Orlando Bus Station to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Minneapolis–Saint Paul International Airport (MSP)plane plane TPA - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 7m
    $195–726

  7. Train, bus

    1. Take the train from Orlando to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    2d 1h
    $1,191–1,837

Orlando to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration33h 29mAverage Duration
Ticket$264Cheapest Price
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Comparing Your Travel Options

Map of how to get from Orlando to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,261.1 mi
  • Duration: 7h 47m

What companies run services between Orlando, FL, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Orlando (MCO) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Orlando Bus Station to Mayo Clinic via Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 33h 29m.

Airlines
Train operators
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Want to know more about travelling around United States

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