Rome2Rio

How to get fromOrlando to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, or car

Find Transport to Mayo Clinic

See all options

There are 7 ways to get from Orlando to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Rochester

    best
    1. Fly from Orlando (MCO) to Rochester (RST)plane plane MCO - RST
    8h 15m
    $102–462

  2. Bus

    1. Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    32h 11m
    $308–554

  3. Train, bus via Madison

    1. Take the train from Orlando to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    2d
    $633–1,246

  4. Drive 1,437.2 mi

    1. Drive from Orlando to Mayo Cliniccar car 1,437.2 mi
    24h 26m
    $263–379

  5. Fly Orlando to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Orlando (MCO) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCO - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 34m
    $254–1,154

  6. Bus to Tampa, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Orlando Bus Station to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Minneapolis–Saint Paul International Airport (MSP)plane plane TPA - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 45m
    $217–780

  7. Train, bus

    1. Take the train from Orlando to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    2d 2h
    $716–1,426

Orlando to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration2d 2hAverage Duration
Ticket$716Cheapest Price
See schedules

Questions & Answers

Map of how to get from Orlando to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,261.2 mi
  • Duration: 8h 15m

What companies run services between Orlando, FL, USA and Mayo Clinic, MN, USA?

American Airlines, Delta, and two other airlines fly from Orlando (MCO) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Orlando RedCoach Station to Mayo Clinic via Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 32h 11m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers