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How to get fromOrlando to Santeeby plane, car, bus (Flixbus), train, bus, or taxi

Find Transport to Santee

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There are 7 ways to get from Orlando to Santee by plane, car, bus (Flixbus), train, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Charleston International Airport, drive

    best
    1. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    3h 46m
    $77–268

  2. Drive 380 mi

    cheapest
    1. Drive from Orlando to Santeecar car 380 mi
    6h 16m
    $70–101

  3. Bus (Flixbus)

    1. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    7h 48m
    $144–206

  4. Train, drive (Amtrak)

    1. Take the train from Orlando to Charleston Amtrak Stationtrain train Silver Meteor
    2. Drive from Charleston Amtrak Station to Santeecar car
    8h 50m
    $140–278

  5. Fly Orlando to Columbia, drive

    1. Fly from Orlando (MCO) to Columbia (CAE)plane plane MCO - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 3m
    $162–868

  6. Bus to Tampa, fly to Charleston International Airport, drive

    1. Take the bus from Orlando Bus Station to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 11m
    $165–383

  7. Bus, taxi

    1. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Walterboro, SCbus bus
    3. Take the taxi from Walterboro, SC to Santeetaxi taxi
    8h
    $153–224

Orlando (MCO) to Charleston International Airport (CHS) flights

Calendar7Weekly Planes
Duration1h 28mAverage Duration
Ticket$65Cheapest Price
See schedules

Questions & Answers

Map of how to get from Orlando to Santee.ExpandLaunch map view
  • Distance: 392.6 mi
  • Duration: 3h 46m

What companies run services between Orlando, FL, USA and Santee, SC, USA?

Flixbus USA operates a bus from Orlando Bus Station to Orangeburg once daily. Tickets cost $60–110 and the journey takes 7h 20m.

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