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How to get fromOrlando to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Find Transport to St. Louis

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There are 6 ways to get from Orlando to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando to Lambert–St. Louis International Airport

    best
    1. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    4h 23m
    $185–495

  2. Bus

    cheapest
    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 55m
    $152–295

  3. Train (Amtrak)

    1. Take the train from Orlando to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    44h 41m
    $654–1,301

  4. Drive 989.1 mi

    1. Drive from Orlando to St. Louiscar car 989.1 mi
    16h 17m
    $181–261

  5. Fly Orlando Sanford to Midamerica St. Louis Airport

    1. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    4h 9m
    $167–515

  6. Bus to Tampa, fly to Lambert–St. Louis International Airport

    1. Take the bus from Orlando Bus Station to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    6h 38m
    $438–2,030

Orlando to St. Louis by bus

Calendar12Weekly Buses
Duration19h 55mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from Orlando to St. Louis.ExpandLaunch map view
  • Distance: 912 mi
  • Duration: 4h 23m

What companies run services between Orlando, FL, USA and St. Louis, MO, USA?

Frontier Airlines, Southwest Airlines, and Delta fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Orlando Bus Station to St Louis Bus Station via Atlanta Bus Station in around 19h 55m.

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