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How to get fromOrleans to Buffaloby plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

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There are 8 ways to get from Orleans to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Barnstable Municipal Airport to Buffalo Niagara International Airport

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF)plane plane HYA - BUF
    7h 42m
    $110–643

  2. Bus

    cheapest
    1. Take the bus from Main Street/CVS/Mobil, Orleans to Hyannis Transportation Centerbus bus
    2. Take the bus from Hyannis Transportation Center to Boston South Stationbus bus
    3. Take the bus from Boston to Buffalobus bus
    15h 7m
    $88–183

  3. Bus, train

    1. Take the bus from Main Street/CVS/Mobil, Orleans to Hyannis Transportation Centerbus bus
    2. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    3. Take the train from Boston to Buffalo Depew Stationtrain train
    17h 57m
    $182–508

  4. Drive 531.4 mi

    1. Drive from Orleans to Buffalocar car 531.4 mi
    9h 26m
    $97–141

  5. Bus to Provincetown Municipal Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Stop & Shop, Orleans to MacMillan Pier, Provincetownbus bus
    2. Fly from Provincetown Municipal Airport (PVC) to Buffalo Niagara International Airport (BUF)plane plane PVC - BUF
    8h 54m
    $108–635

  6. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 53m
    $115–580

  7. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 32m
    $147–645

  8. Bus via Ithaca

    1. Take the bus from Main Street/CVS/Mobil, Orleans to Hyannis Transportation Centerbus bus
    2. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    3. Take the bus from Boston to Ithacabus bus
    4. Take the bus from Ithaca to Buffalobus bus
    17h 21m
    $118–248

Orleans to Buffalo by bus

Calendar7Weekly Buses
Duration15h 7mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Orleans to Buffalo.ExpandLaunch map view
  • Distance: 476.5 mi
  • Duration: 7h 42m

What companies run services between Orleans, MA, USA and Buffalo, NY, USA?

American Airlines, Cape Air, and JetBlue Airways fly from Barnstable Municipal Airport (HYA) to Buffalo Niagara International Airport (BUF) 4 times a day. Alternatively, you can take a bus from Main Street/CVS/Mobil, Orleans to Buffalo via Hyannis Transportation Center, Boston South Station, and Boston in around 15h 7m.

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