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How to get fromOsceola to St. Louisby bus (Greyhound), train, bus, car, shuttle, plane, or taxi

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There are 8 ways to get from Osceola to St. Louis by bus (Greyhound), train, bus, car, shuttle, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Osceola to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    7h 49m
    $82–143

  2. Drive 311.1 mi

    cheapest
    1. Drive from Osceola to St. Louiscar car 311.1 mi
    6h 58m
    $57–82

  3. Train, bus (Amtrak)

    1. Take the train from Osceola Amtrak to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the train from Springfield to St. Louistrain train
    10h 3m
    $128–249

  4. Bus, shuttle to Des Moines, fly to Lambert–St. Louis International Airport

    1. Take the bus from Osceola to Amesbus bus
    2. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    3. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    8h 30m
    $259–1,041

  5. Train, bus via Springfield

    1. Take the train from Osceola Amtrak to Galesburg Amtrak Stationtrain train
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    10h 16m
    $115–212

  6. Bus to Kansas City, fly to Lambert–St. Louis International Airport

    1. Take the bus from Osceola to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane plane MCI - STL
    7h 14m
    $135–671

  7. Taxi, bus to Omaha, fly to Lambert–St. Louis International Airport

    1. Take the taxi from Osceola to Des Moinestaxi taxi
    2. Take the bus from Des Moines to Omaha, NEbus bus
    3. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    7h 40m
    $738–1,078

  8. Bus, shuttle to Des Moines, fly to Abraham Lincoln Capital Airport, train

    1. Take the bus from Osceola to Amesbus bus
    2. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    3. Fly from Des Moines (DSM) to Abraham Lincoln Capital Airport (SPI)plane plane DSM - SPI
    4. Take the train from Springfield to St. Louistrain train
    10h 35m
    $249–869

Osceola to St. Louis by train and bus (Amtrak)

Calendar7Weekly Services
Duration10h 3mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Osceola to St. Louis.ExpandLaunch map view
  • Distance: 397 mi
  • Duration: 7h 49m

What companies run services between Osceola, IA, USA and St. Louis, MO, USA?

You can take a vehicle from Osceola to St Louis Bus Station via Osceola, Kansas City, and Kansas City Bus Station in around 7h 49m.

Airlines
Train operators
Bus operators
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