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How to get fromOsceola, IA to Knoxvilleby bus, shuttle, plane, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

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There are 10 ways to get from Osceola, IA to Knoxville by bus, shuttle, plane, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle to Des Moines, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Osceola to Amesbus bus
    2. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    3. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    8h 29m
    $374–1,400

  2. Drive 795.3 mi

    cheapest
    1. Drive from Osceola, IA to Knoxvillecar car 795.3 mi
    14h 30m
    $146–210

  3. Train, bus

    1. Take the train from Osceola Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 50m
    $600–1,151

  4. Bus

    1. Take the bus from Osceola to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h 12m
    $411–687

  5. Bus to Kansas City, fly to Mcghee Tyson Airport

    1. Take the bus from Osceola to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Mcghee Tyson Airport (TYS)plane plane MCI - TYS
    9h 8m
    $268–1,029

  6. Bus, shuttle to Des Moines, fly to Nashville, drive

    1. Take the bus from Osceola to Amesbus bus
    2. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    3. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    4. Drive from Nashville-Airport-BNA to Knoxvillecar car
    8h 18m
    $239–880

  7. Bus to Kansas City, fly to Nashville, drive

    1. Take the bus from Osceola to Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Nashville (BNA)plane plane MCI - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    9h 51m
    $473–1,209

  8. Bus, shuttle to Des Moines, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take the bus from Osceola to Amesbus bus
    2. Take a shuttle bus from Ames, IA - Iowa State University to Des Moines International Airport, IAshuttle bus
    3. Fly from Des Moines (DSM) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane DSM - ATL
    4. Drive from Atlanta-Airport-ATL to Knoxvillecar car
    9h 48m
    $294–1,090

  9. Train, bus via Ossining

    1. Take the train from Osceola Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 20m
    $555–1,078

  10. Bus via Saint Paul

    1. Take the bus from Osceola to St. Paulbus bus
    2. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 5h
    $383–597

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$216Cheapest Price
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Questions & Answers

Map of how to get from Osceola, IA to Knoxville.ExpandLaunch map view
  • Distance: 785.9 mi
  • Duration: 8h 29m

What companies run services between Osceola, IA, USA and Knoxville, TN, USA?

You can take a bus from Osceola to Knoxville via Kansas City, Kansas City Bus Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 47h 12m.

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