There are 6 ways to get from Osprey to Florida Keys by car, ferry, bus, shuttle, plane, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive, ferry
best- Drive from Osprey to Fort Myers Beach, FLcar
- Take the ferry from Fort Myers Beach, FL to Key West, FLferry Fort Myers Beach
7h 28m$148–158Bus
cheapest- Take the bus from Sarasota Cattlemen Transfer Center to Miami Airport Stationbus FlixBus 2421
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
12h 55m$54–96Bus, shuttle
- Take the bus from Bradenton/Sarasota - Mobil Gas Station to Miami Airportbus Tallahassee
- Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine LabTo the Keys
12h 17m$204–260Drive 322.5 mi
- Drive from Osprey to Florida Keyscar 322.5 mi
6h 28m$59–85Fly to Key West International Airport
- Fly from Sarasota–Bradenton International Airport (SRQ) to Key West International Airport (EYW)plane SRQ - EYW
9h 20m$138–498Fly to Miami International Airport, shuttle
- Fly from Sarasota–Bradenton International Airport (SRQ) to Miami International Airport (MIA)plane SRQ - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
8h 40m$214–638
Osprey to Florida Keys by bus, shuttle, and foot
Comparing Your Travel Options
The cheapest way to get from Osprey to Florida Keys is to bus which costs $50 - $100 and takes 12h 55m.
The fastest way to get from Osprey to Florida Keys is to drive which takes 6h 28m and costs $55 - $85.
No, there is no direct bus from Osprey to Florida Keys. However, there are services departing from N Tamiami Trl @ Ogburn St and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Mall Dr @ Gateway Ave, Sarasota Cattlemen Transfer Center, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 12h 55m.
The distance between Osprey and Florida Keys is 233 miles. The road distance is 324.4 miles.
The best way to get from Osprey to Florida Keys without a car is to bus and shuttle which takes 12h 17m and costs $200 - $260.
It takes approximately 7h 28m to get from Osprey to Florida Keys, including transfers.
Osprey to Florida Keys bus services, operated by Flixbus USA, depart from Sarasota Cattlemen Transfer Center station.
The best way to get from Osprey to Florida Keys is to fly which takes 9h 20m and costs $130 - $500. Alternatively, you can bus, which costs $50 - $100 and takes 12h 55m.
Osprey to Florida Keys bus services, operated by Flixbus USA, arrive at Miami Airport Station.
Yes, the driving distance between Osprey to Florida Keys is 324 miles. It takes approximately 6h 28m to drive from Osprey to Florida Keys.
What companies run services between Osprey, FL, USA and Florida Keys, FL, USA?
American Airlines, Delta, and Allegiant Air fly from Sarasota–Bradenton International Airport (SRQ) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from N Tamiami Trl @ Ogburn St to Florida Keys via Mall Dr @ Gateway Ave, Cattlemen Transit Station, Sarasota Cattlemen Transfer Center, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 55m.
- Website
- delta.com
Flights from Sarasota–Bradenton International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $120–600
- Phone
- +1 877 733 0724
- Website
- RedCoach
Bus from Bradenton/Sarasota - Mobil Gas Station to Miami Airport
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $50–75
- Website
- RedCoach
- Phone
- +1 239-463-5733
- Website
- Key West Express
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- Key West Express
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Booking & Getting There
There are 967+ hotels available in Florida Keys.








