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How to get fromOtay Mesa to San Bernardinoby bus (Flixbus), train (Amtrak), car, or bus

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There are 5 ways to get from Otay Mesa to San Bernardino by bus (Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from San Ysidro Bus Terminal to San Bernardino Downtown Transit Centerbus bus FlixBus 2015 / ...
    5h 15m
    $24–45

  2. Drive 120.8 mi

    cheapest
    1. Drive from Otay Mesa to San Bernardinocar car 120.8 mi
    2h 7m
    $23–32

  3. Train via Santa Ana

    1. Take the train from San Diego to Santa Anatrain train Pacific Surfliner
    2. Take the train from Santa Ana to San Bernardino Depottrain train IE-OC Line
    6h 9m
    $42–92

  4. Train

    1. Take the train from San Diego to Oceansidetrain train Pacific Surfliner
    2. Take the train from Oceanside to San Bernardino - Downtowntrain train IE-OC Line
    6h 23m
    $28–50

  5. Bus via Arrowhead Regional Medical Center

    1. Take the bus from San Ysidro, CA to Valley Blvd - Bloomingtonbus bus San Ysidro
    7h 25m
    $58–89

Otay Mesa to San Bernardino by bus (Flixbus)

Calendar13Weekly Buses
Duration5h 15mAverage Duration
Ticket$24Cheapest Price
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Questions & Answers

Map of how to get from Otay Mesa to San Bernardino.ExpandLaunch map view
  • Distance: 138.3 mi
  • Duration: 5h 15m

What companies run services between Otay Mesa, CA, USA and San Bernardino, CA, USA?

Flixbus USA operates a bus from San Ysidro Bus Terminal to San Bernardino Downtown Transit Center twice daily. Tickets cost $19–35 and the journey takes 3h 30m. Alternatively, you can take a bus from Otay Mesa Rd & Cactus Rd to San Bernardino Depot via Iris Avenue Transit Center, Iris Avenue Station, America Plaza Station, San Diego, and Santa Ana in around 6h 9m.

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