What is the cheapest way to get from Otay Mesa to Santa Ana?

The cheapest way to get from Otay Mesa to Santa Ana is to drive which costs $19 - $28 and takes 1h 52m.

What is the fastest way to get from Otay Mesa to Santa Ana?

The fastest way to get from Otay Mesa to Santa Ana is to drive which takes 1h 52m and costs $19 - $28.

Is there a direct bus between Otay Mesa and Santa Ana?

No, there is no direct bus from Otay Mesa to Santa Ana. However, there are services departing from Otay Mesa Rd & Cactus Rd and arriving at Santa Ana via Iris Avenue Transit Center and San Ysidro. The journey, including transfers, takes approximately 3h 15m.

Is there a direct train between Otay Mesa and Santa Ana?

No, there is no direct train from Otay Mesa station to Santa Ana. However, there are services departing from Iris Avenue Station and arriving at Santa Ana via San Diego. The journey, including transfers, takes approximately 3h 53m.

How far is it from Otay Mesa to Santa Ana?

The distance between Otay Mesa and Santa Ana is 111 miles. The road distance is 105.7 miles.

How do I travel from Otay Mesa to Santa Ana without a car?

The best way to get from Otay Mesa to Santa Ana without a car is to bus which takes 3h 15m and costs $19 - $40.

How long does it take to get from Otay Mesa to Santa Ana?

It takes approximately 3h 15m to get from Otay Mesa to Santa Ana, including transfers.

Where do I catch the Otay Mesa to Santa Ana bus from?

Otay Mesa to Santa Ana bus services, operated by Limousine Express, depart from San Ysidro station.

Where do I catch the Otay Mesa to Santa Ana train from?

Otay Mesa to Santa Ana train services, operated by San Diego Metro Transit, depart from Iris Avenue Station.

Where does the Otay Mesa to Santa Ana bus arrive?

Otay Mesa to Santa Ana bus services, operated by Limousine Express, arrive at Santa Ana station.

Where does the Otay Mesa to Santa Ana train arrive?

Otay Mesa to Santa Ana train services, operated by San Diego Metro Transit, arrive at America Plaza Station.

Can I drive from Otay Mesa to Santa Ana?

Yes, the driving distance between Otay Mesa to Santa Ana is 106 miles. It takes approximately 1h 52m to drive from Otay Mesa to Santa Ana.

Where can I stay near Santa Ana?

There are 1628+ hotels available in Santa Ana.

Otay Mesa to Santa Ana - 4 ways to travel via train, bus, tram, and car

How to get fromOtay Mesa to Santa Ana

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There are 4 ways to get from Otay Mesa to Santa Ana by bus (Greyhound), tram, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from San Ysidro to Santa Anabus Lxus 3126 / ...
3h 15m
$20–40
Tram, train
1. Take the tram from Iris Avenue Station to America Plaza Stationtram Blue
2. Take the train from San Diego to Santa Anatrain Pacific Surfliner
3h 53m
$34–84
Drive 105.1 mi
1. Drive from Otay Mesa to Santa Anacar 105.1 mi
1h 52m
$20–28
Line 929 bus, bus
1. Take the bus from Iris Avenue Transit Center to 12th & Imperial Transit Centerbus 929 / ...
2. Take the bus from San Diego to Santa Anabus Tijuana
4h 29m
$22–38

Otay Mesa to Santa Ana by bus

70Weekly Buses

3h 15mAverage Duration

$20Cheapest Price

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Questions & Answers

Map of how to get from Otay Mesa to Santa Ana.

Launch map view

Distance: 110.8 mi
Duration: 3h 15m

What companies run services between Otay Mesa, CA, USA and Santa Ana, CA, USA?

Limousine Express operates a bus from San Ysidro to Santa Ana 5 times a day, and the journey takes 1h 30m. Three other operators also service this route.

Train operators

Bus operators

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