There are 4 ways to get from Otay Mesa to Santa Ana Regional Transportation Center by bus, tram, train, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Cross Border Xpress to Santa Anabus 2 / ...
2h 13m$41–62Drive 104.7 mi
cheapest- Drive from Otay Mesa to Santa Ana Regional Transportation Centercar 104.7 mi
1h 51m$20–28Tram, train
- Take the tram from Iris Avenue Station to America Plaza Stationtram Blue
- Take the train from San Diego to Santa Anatrain Pacific Surfliner
3h 53m$32–79Line 929 bus, bus
- Take the bus from Iris Avenue Transit Center to 12th & Imperial Transit Centerbus 929 / ...
- Take the bus from San Diego to Santa Anabus Tijuana
4h 29m$22–39
Otay Mesa to Santa Ana Regional Transportation Center by bus, tram, and train
Questions & Answers
The cheapest way to get from Otay Mesa to Santa Ana Regional Transportation Center is to drive which costs $19 - $28 and takes 1h 51m.
The fastest way to get from Otay Mesa to Santa Ana Regional Transportation Center is to drive which takes 1h 51m and costs $19 - $28.
No, there is no direct bus from Otay Mesa to Santa Ana Regional Transportation Center. However, there are services departing from Cross Border Xpress and arriving at Santa Ana via . The journey, including transfers, takes approximately 2h 13m.
No, there is no direct train from Otay Mesa station to Santa Ana Regional Transportation Center. However, there are services departing from Iris Avenue Station and arriving at Santa Ana via San Diego. The journey, including transfers, takes approximately 3h 53m.
The distance between Otay Mesa and Santa Ana Regional Transportation Center is 108 miles. The road distance is 105.3 miles.
The best way to get from Otay Mesa to Santa Ana Regional Transportation Center without a car is to bus which takes 2h 13m and costs $40 - $65.
It takes approximately 2h 13m to get from Otay Mesa to Santa Ana Regional Transportation Center, including transfers.
Otay Mesa to Santa Ana Regional Transportation Center bus services, operated by Limousine Express, depart from Cross Border Xpress station.
Otay Mesa to Santa Ana Regional Transportation Center train services, operated by San Diego Metro Transit, depart from Iris Avenue Station.
Otay Mesa to Santa Ana Regional Transportation Center bus services, operated by Limousine Express, arrive at Santa Ana station.
What companies run services between Otay Mesa, CA, USA and Santa Ana Regional Transportation Center, CA, USA?
Limousine Express operates a bus from Cross Border Xpress to Santa Ana every 3 hours. Tickets cost $30–45 and the journey takes 2h 10m. CBX Cross Border Express also services this route twice daily.
- Phone
- +1 619-557-4555
- Website
- MTS
Tram from Iris Avenue Station to America Plaza Station
- Ave. Duration
- 38 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–14
- Website
- MTS
- Schedules at
- MTS Schedules
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from San Diego to Santa Ana
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- $28–60
- Website
- Amtrak
- Phone
- +1 866 691 9732
- [email protected]
- Website
- Limousine Express
Bus from Cross Border Xpress to Santa Ana
- Ave. Duration
- 2h 10m
- Frequency
- Every 3 hours
- Estimated price
- $30–45
- Website
- Limousine Express
- One Way
- $30–45
- [email protected]
- Website
- CBX Cross Border Express
Bus from Cross Border Xpress to Santa Ana
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $27–40
- Schedules at
- CBX Cross Border Express
- Phone
- +1 619-557-4555
- Website
- MTS
Bus from Iris Avenue Transit Center to 12th & Imperial Transit Center
- Ave. Duration
- 1h 14m
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- MTS
- Schedules at
- MTS Schedules
- One Way - Adult/Youth
- $2–5
- Phone
- +1-800-231-2222
- [email protected]
- Website
- Greyhound Mexico
Bus from San Diego to Santa Ana
- Ave. Duration
- 1h 55m
- Frequency
- 3 times a day
- Estimated price
- $18–29
- Schedules at
- Greyhound Mexico
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Otay Mesa to Santa Ana Regional Transportation Center train services, operated by San Diego Metro Transit, arrive at America Plaza Station.
Yes, the driving distance between Otay Mesa to Santa Ana Regional Transportation Center is 105 miles. It takes approximately 1h 51m to drive from Otay Mesa to Santa Ana Regional Transportation Center.
There are 1187+ hotels available in Santa Ana Regional Transportation Center.


















