There are 7 ways to get from Otay Mesa to Tucson by bus, tram, plane, bus (Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Line 905 bus, tram, fly to Tucson
best- Take the bus from Otay Mesa Rd & Cactus Rd to Iris Avenue Transit Centerbus
- Take the tram from Iris Avenue Station to America Plaza Stationtram
- Fly from San Diego International Airport (SAN) to Tucson (TUS)plane SAN - TUS
4h 48m$446–824Drive 401.5 mi
cheapest- Drive from Otay Mesa to Tucsoncar 401.5 mi
6h 47m$74–106Bus via Phoenix
- Take the bus from San Ysidro Bus Terminal to Phoenix Bus Stationbus Greyhound US0851S
- Take the bus from Phoenix Bus Station to Tucsonbus FlixBus 2054
12h 55mTrain (Amtrak)
- Take the train from San Diego to Los Angelestrain Pacific Surfliner
- Take the train from Los Angeles to Tucson Amtrak Stationtrain Texas Eagle / ...
15h 26m$204–434Fly to Phoenix, bus
- Fly from San Diego International Airport (SAN) to Phoenix (PHX)plane SAN - PHX
- Take the bus from Sky Harbor International Airport to University of Phoenixbus
6h 27m$166–1,059Bus, train
- Take the bus from San Ysidro Bus Terminal to Yuma County Area Transitbus Greyhound US0851S
- Take the train from Yuma Amtrak to Tucson Amtrak Stationtrain Texas Eagle / ...
13h 22m$114–242Bus
- Take the bus from San Ysidro, CA to Valley Blvd - Bloomingtonbus San Ysidro
- Take the bus from Bloomington to Tucsonbus San Jose / ...
16h 8m$110–165
San Diego International Airport (SAN) to Tucson (TUS) flights
Questions & Answers
The cheapest way to get from Otay Mesa to Tucson is to drive which costs $70 - $110 and takes 6h 47m.
The fastest way to get from Otay Mesa to Tucson is to line 905 bus and tram and fly which takes 4h 48m and costs $440 - $850.
No, there is no direct bus from Otay Mesa to Tucson. However, there are services departing from Otay Mesa Rd & Cactus Rd and arriving at Tucson via Iris Avenue Transit Center, San Ysidro Bus Terminal and Phoenix Bus Station. The journey, including transfers, takes approximately 12h 55m.
No, there is no direct train from Otay Mesa station to Tucson station. However, there are services departing from Iris Avenue Station and arriving at Tucson Amtrak Station via San Diego and Los Angeles. The journey, including transfers, takes approximately 15h 26m.
The distance between Otay Mesa and Tucson is 400 miles. The road distance is 403.8 miles.
The best way to get from Otay Mesa to Tucson without a car is to bus via Phoenix which takes 12h 55m and costs .
It takes approximately 4h 48m to get from Otay Mesa to Tucson, including transfers.
Otay Mesa to Tucson bus services, operated by Greyhound USA, depart from San Ysidro Bus Terminal station.
Otay Mesa to Tucson train services, operated by Amtrak, depart from San Diego station.
The best way to get from Otay Mesa to Tucson is to bus via Phoenix which takes 12h 55m and costs . Alternatively, you can train, which costs $200 - $440 and takes 15h 26m.
What companies run services between Otay Mesa, CA, USA and Tucson, AZ, USA?
You can take a bus from Otay Mesa Rd & Cactus Rd to Tucson via Iris Avenue Transit Center, San Ysidro Bus Terminal, and Phoenix Bus Station in around 12h 55m. Alternatively, you can take a bus from Otay Mesa Rd & Cactus Rd to Tucson Amtrak Station via Iris Avenue Transit Center, Iris Avenue Station, America Plaza Station, San Diego, and Los Angeles in around 15h 26m.
- Website
- southwest.com
Flights from San Diego International Airport to Tucson
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $65–400
Flights from San Diego International Airport to Tucson via Phoenix
- Ave. Duration
- 3h 22m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $70–410
Flights from San Diego International Airport to Tucson via Las Vegas
- Ave. Duration
- 3h 42m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $85–470
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $40–270
- Website
- aa.com
Flights from San Diego International Airport to Tucson via Phoenix
- Ave. Duration
- 3h 29m
- When
- Every day
- Estimated price
- $70–410
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $40–270
- Website
- alaskaair.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $160–240
- Website
- flyfrontier.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $110–350
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Tram from Iris Avenue Station to America Plaza Station
- Ave. Duration
- 38 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–14
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from San Diego to Los Angeles
- Ave. Duration
- 2h 56m
- Frequency
- Hourly
- Estimated price
- $40–85
- Website
- https://www.amtrak.com/home.html
Train from Los Angeles to Tucson Amtrak Station
- Ave. Duration
- 9h 38m
- Frequency
- 6 times a week
- Estimated price
- $160–330
- Website
- https://www.amtrak.com/home.html
Train from Yuma Amtrak to Tucson Amtrak Station
- Ave. Duration
- 4h 51m
- Frequency
- 6 times a week
- Estimated price
- $80–170
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Bus from Otay Mesa Rd & Cactus Rd to Iris Avenue Transit Center
- Ave. Duration
- 13 min
- Frequency
- Hourly
- Estimated price
- $2–5
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- One Way - Adult/Youth
- $2–5
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from San Ysidro Bus Terminal to Phoenix Bus Station
- Ave. Duration
- 8h
- Frequency
- Once daily
- Estimated price
- $60–120
- Website
- https://www.greyhound.com/
Bus from San Ysidro Bus Terminal to Yuma County Area Transit
- Ave. Duration
- 4h 35m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
- Website
- greyhound.com
Bus from San Ysidro Bus Terminal to Phoenix Bus Station
- Ave. Duration
- 7h 50m
- Frequency
- 5 times a week
- Schedules at
- greyhound.com
Bus from San Ysidro Bus Terminal to Yuma County Area Transit
- Ave. Duration
- 4h 25m
- Frequency
- 5 times a week
- Schedules at
- greyhound.com
- Website
- flixbus.com
Bus from Phoenix Bus Station to Tucson
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Schedules at
- flixbus.com
- Phone
- +1 928-350-8466
- Website
- arizonashuttle.com
Bus from Sky Harbor International Airport to University of Phoenix
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- $50–85
- Book at
- https://groometransportation.com/phoenix-airport/?&sd_client_id=d8dca231-4b1d-4fa2-b53c-9a6a93b47ffd
- Phone
- +1 833 766 3553
- Website
- tufesainternacional.com
Bus from San Ysidro, CA to Valley Blvd - Bloomington
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $50–75
- Schedules at
- tufesainternacional.com
- Adult One way
- $50–75
Bus from Bloomington to Tucson
- Ave. Duration
- 7h 40m
- Frequency
- Every 4 hours
- Estimated price
- $80–110
- Schedules at
- tufesainternacional.com
- Adult One way
- $80–110
- Phone
- +52 644 410 2444
- [email protected]
- Website
- tufesa.com.mx
Bus from Bloomington to Tucson
- Ave. Duration
- 7h 50m
- Frequency
- Twice daily
- Estimated price
- $55–80
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $55–80
- Titanium
- $60–75
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More Questions & Answers
Otay Mesa to Tucson bus services, operated by Greyhound USA, arrive at Phoenix Bus Station.
Otay Mesa to Tucson train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between Otay Mesa to Tucson is 404 miles. It takes approximately 6h 47m to drive from Otay Mesa to Tucson.
There are 719+ hotels available in Tucson.






















