There are 7 ways to get from Otay Mesa to Tucson by bus, tram, plane, train, train (Amtrak), car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Line 905 bus, tram, fly to Tucson
best- Take the bus from Otay Mesa Rd & Cactus Rd to Iris Avenue Transit Centerbus
- Take the tram from Iris Avenue Station to Civic Center Stationtram
- Fly from San Diego International Airport (SAN) to Tucson (TUS)plane SAN - TUS
4h 45m$506–774Drive 401.5 mi
cheapest- Drive from Otay Mesa to Tucsoncar 401.5 mi
6h 47m$71–103Bus, train
- Take the bus from San Ysidro Bus Terminal to Yuma County Area Transitbus Greyhound US0851S
- Take the train from Yuma Amtrak to Tucson Amtrak Stationtrain Texas Eagle / ...
13h 22m$168–287Train (Amtrak)
- Take the train from San Diego to Los Angelestrain Pacific Surfliner
- Take the train from Los Angeles to Tucson Amtrak Stationtrain Texas Eagle / ...
15h 28m$344–559Fly to Phoenix, bus
- Fly from San Diego International Airport (SAN) to Phoenix (PHX)plane SAN - PHX
- Take the bus from Sky Harbor International Airport to University of Phoenixbus
6h 24m$126–299Bus via Yuma
- Take the bus from San Ysidro Bus Terminal to Yuma County Area Transitbus
- Take the bus from Yuma County Area Transit to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Tucson Downtownbus
14h 17m$88–142Bus
- Take the bus from San Ysidro, CA to Valley Blvd - Bloomingtonbus San Ysidro
- Take the bus from Bloomington to Tucsonbus San Jose / ...
16h 8m$104–155
Otay Mesa to Tucson by bus, tram, and train
Comparing Your Travel Options
The cheapest way to get from Otay Mesa to Tucson is to drive which costs $70 - $110 and takes 6h 47m.
The fastest way to get from Otay Mesa to Tucson is to line 905 bus and tram and fly which takes 4h 45m and costs $500 - $800.
No, there is no direct bus from Otay Mesa to Tucson. However, there are services departing from Otay Mesa Rd & Cactus Rd and arriving at Broadway/Country Club via Iris Avenue Transit Center, San Ysidro Bus Terminal, Yuma County Area Transit, Phoenix Sky Harbor Airport/44th Street Sky Train Station and Downtown Ronstadt Center. The journey, including transfers, takes approximately 14h 17m.
No, there is no direct train from Otay Mesa station to Tucson station. However, there are services departing from Iris Avenue Station and arriving at Tucson Amtrak Station via San Diego and Los Angeles. The journey, including transfers, takes approximately 15h 28m.
The distance between Otay Mesa and Tucson is 400 miles. The road distance is 403.8 miles.
The best way to get from Otay Mesa to Tucson without a car is to bus and train which takes 13h 22m and costs $160 - $290.
It takes approximately 4h 45m to get from Otay Mesa to Tucson, including transfers.
Otay Mesa to Tucson bus services, operated by Greyhound USA, depart from San Ysidro Bus Terminal station.
Otay Mesa to Tucson train services, operated by Amtrak, depart from San Diego station.
The best way to get from Otay Mesa to Tucson is to train which takes 15h 28m and costs $340 - $600. Alternatively, you can bus via Yuma, which costs $85 - $150 and takes 14h 17m.
What companies run services between Otay Mesa, CA, USA and Tucson, AZ, USA?
You can take a bus from Otay Mesa Rd & Cactus Rd to Tucson Amtrak Station via Iris Avenue Transit Center, Iris Avenue Station, America Plaza Station, San Diego, and Los Angeles in around 15h 28m. Alternatively, you can take a bus from Otay Mesa Rd & Cactus Rd to Broadway/Country Club via Iris Avenue Transit Center, San Ysidro Bus Terminal, Yuma County Area Transit, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tucson Downtown, and Downtown Ronstadt Center in around 14h 17m.
- Website
- southwest.com
Flights from San Diego International Airport to Tucson
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $50–330
Flights from San Diego International Airport to Tucson via Phoenix
- Ave. Duration
- 3h 31m
- When
- Saturday, Tuesday, and Wednesday
- Estimated price
- $55–340
Flights from San Diego International Airport to Tucson via Las Vegas
- Ave. Duration
- 3h 45m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $65–370
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 22m
- When
- Every day
- Estimated price
- $30–230
- Website
- aa.com
Flights from San Diego International Airport to Tucson via Phoenix
- Ave. Duration
- 3h 34m
- When
- Every day
- Estimated price
- $55–340
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $30–230
- Website
- alaskaair.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $120–650
- Website
- flyfrontier.com
Flights from San Diego International Airport to Phoenix
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $70–180
- Phone
- +1 619-557-4555
- Website
- MTS
Tram from Iris Avenue Station to Civic Center Station
- Ave. Duration
- 36 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–14
- Website
- MTS
- Schedules at
- MTS Schedules
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Yuma Amtrak to Tucson Amtrak Station
- Ave. Duration
- 4h 51m
- Frequency
- 6 times a week
- Estimated price
- $130–220
- Website
- Amtrak
Train from San Diego to Los Angeles
- Ave. Duration
- 2h 56m
- Frequency
- Hourly
- Estimated price
- $70–110
- Website
- Amtrak
Train from Los Angeles to Tucson Amtrak Station
- Ave. Duration
- 9h 38m
- Frequency
- 6 times a week
- Estimated price
- $270–430
- Website
- Amtrak
- Phone
- +1 619-557-4555
- Website
- MTS
Bus from Otay Mesa Rd & Cactus Rd to Iris Avenue Transit Center
- Ave. Duration
- 13 min
- Frequency
- Hourly
- Estimated price
- $2–5
- Website
- MTS
- Schedules at
- MTS Schedules
- One Way - Adult/Youth
- $2–5
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from San Ysidro Bus Terminal to Yuma County Area Transit
- Ave. Duration
- 4h 35m
- Frequency
- Twice daily
- Estimated price
- $35–60
- Website
- Greyhound
Bus from San Ysidro Bus Terminal to Yuma County Area Transit
- Ave. Duration
- 4h 35m
- Frequency
- Twice daily
- Estimated price
- $35–60
- Website
- Greyhound
- Phone
- +1 928-350-8466
- Website
- arizonashuttle.com
Bus from Sky Harbor International Airport to University of Phoenix
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- $50–85
- Book at
- Groome Transportation - Phoenix, AZ
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Yuma County Area Transit to Phoenix Sky Harbor Airport/44th Street Sky Train Station
- Ave. Duration
- 3h 19m
- Frequency
- 6 times a week
- Estimated price
- $30–45
- Schedules at
- Flixbus USA
Bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Tucson Downtown
- Ave. Duration
- 2h 10m
- Frequency
- Every 4 hours
- Estimated price
- $18–27
- Schedules at
- Flixbus USA
- Phone
- +1 833 766 3553
- Website
- Tufesa
Bus from San Ysidro, CA to Valley Blvd - Bloomington
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $50–75
- Schedules at
- Tufesa
- Adult One way
- $50–75
Bus from Bloomington to Tucson
- Ave. Duration
- 7h 40m
- Frequency
- Every 4 hours
- Estimated price
- $80–110
- Schedules at
- Tufesa
- Adult One way
- $80–110
- Phone
- +52 644 410 2444
- [email protected]
- Website
- tufesa.com.mx
Bus from Bloomington to Tucson
- Ave. Duration
- 7h 50m
- Frequency
- Twice daily
- Estimated price
- $50–70
- Schedules at
- tufesa.com.mx
- Book at
- tufesa.com.mx
- Plus
- $50–70
- Titanium
- $55–65
Want to know more about travelling around United States
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Booking & Getting There
Otay Mesa to Tucson bus services, operated by Greyhound USA, arrive at Yuma County Area Transit station.
Tucson is 1h ahead of Otay Mesa. It is currently 2:52 PM in Otay Mesa and 3:52 PM in Tucson.
Otay Mesa to Tucson train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between Otay Mesa to Tucson is 404 miles. It takes approximately 6h 47m to drive from Otay Mesa to Tucson.
There are 826+ hotels available in Tucson.























