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How to get fromOtay Mesa to Tucsonby bus, tram, plane, train, train (Amtrak), car, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 7 ways to get from Otay Mesa to Tucson by bus, tram, plane, train, train (Amtrak), car, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 905 bus, tram, fly to Tucson

    best
    1. Take the bus from Otay Mesa Rd & Cactus Rd to Iris Avenue Transit Centerbus bus
    2. Take the tram from Iris Avenue Station to Civic Center Stationtram tram
    3. Fly from San Diego International Airport (SAN) to Tucson (TUS)plane plane SAN - TUS
    4h 40m
    $506–774
  2. Drive  401.5 mi

    cheapest
    1. Drive from Otay Mesa to Tucsoncar car 401.5 mi
    6h 47m
    $71–103
  3. Bus, train

    1. Take the bus from San Ysidro Bus Terminal to Yuma County Area Transitbus bus Greyhound US0851S
    2. Take the train from Yuma Amtrak to Tucson Amtrak Stationtrain train Texas Eagle / ...
    13h 22m
    $168–282
  4. Train (Amtrak)

    1. Take the train from San Diego to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to Tucson Amtrak Stationtrain train Texas Eagle / ...
    15h 28m
    $344–559
  5. Fly to Phoenix, bus

    1. Fly from San Diego International Airport (SAN) to Phoenix (PHX)plane plane SAN - PHX
    2. Take the bus from Sky Harbor International Airport to University of Phoenixbus bus
    6h 24m
    $126–299
  6. Bus

    1. Take the bus from San Ysidro Bus Terminal to El Centro Bus Stopbus bus
    2. Take the bus from El Centro Bus Stop to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus bus
    3. Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Tucsonbus bus
    14h 24m
    $86–143
  7. Bus via Los Angeles

    1. Take the bus from San Ysidro to Huntington Parkbus bus Lxus 3126 / ...
    2. Take the bus from Huntington Park to Tucsonbus bus Huntington Park / ...
    15h 20m
    $84–135

Otay Mesa to Tucson by bus, tram, and train

Calendar6Weekly Services
Duration13h 22mAverage Duration
Ticket$168Cheapest Price
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Comparing Your Travel Options

What companies run services between Otay Mesa, CA, USA and Tucson, AZ, USA?

You can take a bus from Otay Mesa Rd & Cactus Rd to Tucson Amtrak Station via Iris Avenue Transit Center, Iris Avenue Station, America Plaza Station, San Diego, and Los Angeles in around 15h 28m. Alternatively, you can take a bus from Otay Mesa Rd & Cactus Rd to Tucson via Iris Avenue Transit Center, San Ysidro Bus Terminal, El Centro Bus Stop, and Phoenix Sky Harbor Airport/44th Street Sky Train Station in around 14h 24m.

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