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How to get fromOttawa to Mayo Clinicby plane, bus, train, bus (Flixbus), or car

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There are 8 ways to get from Ottawa to Mayo Clinic by plane, bus, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ottawa Macdonald-Cartier International Airport to Rochester

    best
    1. Fly from Ottawa Macdonald-Cartier International Airport (YOW) to Rochester (RST)plane plane YOW - RST
    8h 25m
    $93–433

  2. Bus, train

    1. Take the bus from Ottawa to Syracuse Bus Stationbus bus
    2. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    28h 11m
    $316–620

  3. Bus

    1. Take the bus from Ottawa to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    28h 43m
    $213–335

  4. Drive 1,024.3 mi

    1. Drive from Ottawa to Mayo Cliniccar car 1,024.3 mi
    20h 44m
    $235–339

  5. Fly Ottawa Macdonald-Cartier International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Ottawa Macdonald-Cartier International Airport (YOW) to Minneapolis–Saint Paul International Airport (MSP)plane plane YOW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 22m
    $375–1,255

  6. Train to Montréal–Pierre Elliott Trudeau International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Ottawa to Dorvaltrain train
    2. Fly from Montréal–Pierre Elliott Trudeau International Airport (YUL) to Minneapolis–Saint Paul International Airport (MSP)plane plane YUL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 34m
    $421–1,560

  7. Fly Ottawa Macdonald-Cartier International Airport to Mason City, bus

    1. Fly from Ottawa Macdonald-Cartier International Airport (YOW) to Mason City (MCW)plane plane YOW - MCW
    2. Take the bus from Mason City to Albert Leabus bus
    3. Take the bus from Albert Lea to Rochesterbus bus
    14h 2m

  8. Train, bus

    1. Take the train from Ottawa to Toronto Union Stationtrain train
    2. Take the train from Toronto Union Station to Buffalotrain train
    3. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    5. Take the bus from St. Paul to Rochester, MNbus bus
    32h 12m
    $433–1,067

Ottawa to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration32h 12mAverage Duration
Ticket$433Cheapest Price
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Questions & Answers

Map of how to get from Ottawa to Mayo Clinic.ExpandLaunch map view
  • Distance: 846.7 mi
  • Duration: 8h 25m

What companies run services between Ottawa, ON, Canada and Mayo Clinic, MN, USA?

United Airlines, American Airlines, and two other airlines fly from Ottawa Macdonald-Cartier International Airport (YOW) to Rochester (RST) 3 times a day. Alternatively, you can take a bus from Ottawa to Mayo Clinic via Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 28h 43m.

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