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How to get fromOttawa to Mayo Clinicby plane, bus, bus (Flixbus), train, or car

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There are 7 ways to get from Ottawa to Mayo Clinic by plane, bus, bus (Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ottawa Macdonald-Cartier International Airport to Minneapolis–Saint Paul International Airport, bus

    best
    1. Fly from Ottawa Macdonald-Cartier International Airport (YOW) to Minneapolis–Saint Paul International Airport (MSP)plane plane YOW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 11m
    $153–603

  2. Fly Ottawa Macdonald-Cartier International Airport to Rochester

    cheapest
    1. Fly from Ottawa Macdonald-Cartier International Airport (YOW) to Rochester (RST)plane plane YOW - RST
    9h 54m
    $89–483

  3. Bus

    1. Take the bus from Ottawa to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    28h 3m
    $205–304

  4. Train, bus via Milwaukee

    1. Take the train from Ottawa to Toronto Union Stationtrain train
    2. Take the train from Toronto Union Station to Buffalotrain train
    3. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Milwaukeetrain train
    5. Take the bus from Milwaukee to Rochesterbus bus
    30h 20m
    $509–1,031

  5. Drive  1,024.4 mi

    1. Drive from Ottawa to Mayo Cliniccar car 1,024.4 mi
    20h 42m
    $235–339

  6. Train to Montréal–Pierre Elliott Trudeau International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Ottawa to Dorvaltrain train
    2. Fly from Montréal–Pierre Elliott Trudeau International Airport (YUL) to Minneapolis–Saint Paul International Airport (MSP)plane plane YUL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 42m
    $449–1,757

  7. Train, bus

    1. Take the train from Ottawa to Toronto Union Stationtrain train
    2. Take the train from Toronto Union Station to Buffalotrain train
    3. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    5. Take the bus from St. Paul to Rochesterbus bus
    32h 7m
    $642–1,246

Ottawa to Mayo Clinic by bus and foot

Calendar3Weekly Services
Duration28h 3mAverage Duration
Ticket$205Cheapest Price
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Comparing Your Travel Options

Map of how to get from Ottawa to Mayo Clinic.ExpandLaunch map view
  • Distance: 943.8 mi
  • Duration: 10h 11m

What companies run services between Ottawa, ON, Canada and Mayo Clinic, MN, USA?

You can take a bus from Ottawa to Mayo Clinic via Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 28h 3m. Alternatively, United Airlines, American Airlines, and three other airlines fly from Ottawa Macdonald-Cartier International Airport (YOW) to Rochester (RST) every 4 hours.

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