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How to get fromPaducah to Saint Charlesby bus (Flixbus), car, or plane

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There are 3 ways to get from Paducah to Saint Charles by bus (Flixbus), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Paducah Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    5h 5m
    $40–60
  2. Drive 193.2 mi

    cheapest
    1. Drive from Paducah to Saint Charlescar car 193.2 mi
    3h 20m
    $36–51
  3. Fly

    1. Fly from Barkley Regional Airport (PAH) to Lambert–St. Louis International Airport (STL)plane plane PAH - STL
    6h 36m
    $130–585

Barkley Regional Airport (PAH) to Lambert–St. Louis International Airport (STL) flights

Calendar8Weekly Planes
Duration5h 48mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

What companies run services between Paducah, KY, USA and Saint Charles, MO, USA?

Jefferson Lines operates a bus from Paducah Bus Station to St Louis Bus Station once daily. Tickets cost $45–65 and the journey takes 3h 35m. Flixbus USA also services this route 5 times a week. Alternatively, United Airlines flies from Barkley Regional Airport (PAH) to Lambert–St. Louis International Airport (STL) once daily.

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