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How to get fromPainesville to Louisvilleby bus (Amtrak), train, bus, car, plane, or bus (Greyhound, Amtrak)

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There are 7 ways to get from Painesville to Louisville by bus (Amtrak), train, bus, car, plane, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    13h 9m
    $57–163

  2. Train, bus via Chicago (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 26m
    $181–450

  3. Drive  373.1 mi

    1. Drive from Painesville to Louisvillecar car 373.1 mi
    6h 22m
    $69–99

  4. Fly

    1. Fly from Cleveland-Hopkins International Airport (CLE) to Louisville International Airport (SDF)plane plane CLE - SDF
    8h 32m
    $117–764

  5. Bus via W. Washington St. & Liberty St.

    1. Take the bus from Cleveland to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    13h 25m
    $71–153

  6. Train, bus

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    13h 37m
    $75–193

  7. Train, bus #2

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    13h 53m
    $89–183

Painesville to Louisville by bus

Calendar7Weekly Buses
Duration13h 9mAverage Duration
Ticket$57Cheapest Price
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Comparing Your Travel Options

Map of how to get from Painesville to Louisville.ExpandLaunch map view
  • Distance: 484.8 mi
  • Duration: 13h 9m

What companies run services between Painesville, OH, USA and Louisville, KY, USA?

You can take a bus from Wood St. & Sterling Ave. to Louisville, KY via Lakeland Transit Center, Lakeland Transit Center Pnr, Superior Ave. & E.13Th St., Cleveland, Toledo, and Indianapolis Union Station in around 13h 9m. Alternatively, Delta, Southwest Airlines, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Louisville International Airport (SDF) hourly.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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