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How to get fromPalatine to Mayo Clinicby train, plane, bus, or car

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There are 7 ways to get from Palatine to Mayo Clinic by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Palatine to Irving Parktrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 45m
    $47–340

  2. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    9h 48m
    $78–132

  3. Train, bus via Saint Paul

    1. Take the train from Palatine to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    12h 11m
    $166–319

  4. Drive 312.3 mi

    1. Drive from Palatine to Mayo Cliniccar car 312.3 mi
    5h 41m
    $57–83

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 28m
    $278–512

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Palatine to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 19m
    $134–543

  7. Train, bus

    1. Take the train from Palatine to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 19m
    $105–169

Palatine to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration12h 11mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Palatine to Mayo Clinic.ExpandLaunch map view
  • Distance: 306.9 mi
  • Duration: 4h 45m

What companies run services between Palatine, IL, USA and Mayo Clinic, MN, USA?

You can take a train from Palatine to Mayo Clinic via Des Plaines, Des Plaines Metra Station, Multi-Modal/Rental Car Facility, Madison, and Rochester in around 9h 48m.

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