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How to get fromPalatine to St. Louisby train, plane, train (Amtrak), bus (Flixbus), car, or bus

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There are 6 ways to get from Palatine to St. Louis by train, plane, train (Amtrak), bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly

    best
    1. Take the train from Palatine to Irving Parktrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 2m
    $279–713

  2. Drive 300.1 mi

    cheapest
    1. Drive from Palatine to St. Louiscar car 300.1 mi
    5h 1m
    $55–80

  3. Train

    1. Take the train from Palatine to Chicago OTCtrain train Up-Nw
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 48m
    $98–199

  4. Bus

    1. Take the bus from Woodfield Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus 2510 / ...
    9h 9m
    $76–113

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Palatine to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 49m
    $90–564

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 51m
    $523–898

Palatine to St. Louis by train and bus

Calendar38Weekly Services
Duration6h 48mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Palatine to St. Louis.ExpandLaunch map view
  • Distance: 302.1 mi
  • Duration: 4h 2m

What companies run services between Palatine, IL, USA and St. Louis, MO, USA?

You can take a train from Palatine to St. Louis via Chicago OTC, Madison & Canal, Clinton & Jackson, and Chicago Union Station in around 6h 48m. Alternatively, you can take a bus from Rand/Evergreen to St Louis Bus Station via Northwest Transportation Center, Woodfield Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 9h 9m.

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