There are 7 ways to get from Palermo (Region) to Brindisi by bus, plane, train (Trenitalia), night train, train, ferry, car, or car ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, fly
best- Take the bus from Vicari to Palermobus
- Fly from Palermo Airport (PMO) to Brindisi Airport (BDS)plane PMO - BDS
5h 3mTrain (Trenitalia)
cheapest- Take the train from Termini Imerese to Lamezia Terme C.train Ic
- Take the train from Lamezia Terme C. to Brindisitrain Ic
12h 8m€89–162Bus
- Take the bus from Vicari to Palermobus
- Take the bus from Palermo Via Tommaso Fazello to Catania Central Bus Stationbus
- Take the bus from Catania, Via D'Amico to Brindisibus
14h 9mBus, night train, train
- Take the bus from Vicari to Palermobus
- Take the nighttrain from Palermo Centrale to Lamezia Terme C.nighttrain Ini
- Take the train from Lamezia Terme C. to Brindisitrain Ic
13h 55mBus, train, ferry
- Take the bus from Vicari to Palermobus
- Take the train from Palermo Centrale to Messina Centraletrain Re
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Amanteatrain Re
- Take the train from Amantea to Brindisitrain Ic
12h 40mBus via Tarsia
- Take the bus from Vicari to Palermobus
- Take the bus from Palermo Piazza Cairoli to Tarsia A3bus
- Take the bus from Tarsia A3 to Brindisibus
20h 55mDrive, car ferry
- Drive from Palermo (Region) to Tresmestiericar
- Take the carferry from Tresmestieri to Villa S. Giovannicarferry
- Drive from Villa S. Giovanni to Brindisicar
8h 16m€126–198
Palermo Airport (PMO) to Brindisi Airport (BDS) flights
Comparing Your Travel Options
The cheapest way to get from Palermo (Region) to Brindisi is to train which costs €85 - €170 and takes 12h 8m.
The fastest way to get from Palermo (Region) to Brindisi is to drive and car ferry which takes 8h 16m and costs €120 - €200.
No, there is no direct bus from Palermo (Region) to Brindisi. However, there are services departing from Vicari and arriving at Brindisi via Palermo Via Tommaso Fazello and Catania, Via D'Amico. The journey, including transfers, takes approximately 14h 9m.
No, there is no direct train from Palermo (Region) to Brindisi. However, there are services departing from Roccapalumba-Alia and arriving at Brindisi via Termini Imerese and Lamezia Terme C.. The journey, including transfers, takes approximately 12h 8m.
The distance between Palermo (Region) and Brindisi is 586 km.
The best way to get from Palermo (Region) to Brindisi without a car is to train which takes 12h 8m and costs €85 - €170.
It takes approximately 5h 3m to get from Palermo (Region) to Brindisi, including transfers.
Palermo (Region) to Brindisi bus services, operated by Azienda Siciliana Trasporti, depart from Vicari station.
Palermo (Region) to Brindisi train services, operated by Trenitalia Intercity, depart from Termini Imerese station.
The best way to get from Palermo (Region) to Brindisi is to train which takes 12h 8m and costs €85 - €170. Alternatively, you can bus, which costs and takes 14h 9m.
What companies run services between Palermo (Region), Sicily, Italy and Brindisi, Italy?
You can take a vehicle from Palermo (Region) to Brindisi via Roccapalumba-Alia, Termini Imerese, and Lamezia Terme C. in around 12h 8m. Alternatively, you can take a bus from Vicari to Brindisi via Palermo, Palermo Via Tommaso Fazello, Catania Central Bus Station, and Catania, Via D'Amico in around 14h 9m.
- Website
- ita-airways.com
Flights from Palermo Airport to Brindisi Airport via Rome
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- €95–140
- Website
- ryanair.com
Flights from Palermo Airport to Brindisi Airport
- Ave. Duration
- 1h 15m
- When
- Wednesday
- Estimated price
- €50–160
Flights from Palermo Airport to Brindisi Airport via Rome
- Ave. Duration
- 3h 30m
- When
- Wednesday
- Estimated price
- €50–160
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Termini Imerese to Lamezia Terme C.
- Ave. Duration
- 5h 20m
- Frequency
- 4 times a day
- Estimated price
- €30–60
- Website
- Trenitalia Intercity
Train from Lamezia Terme C. to Brindisi
- Ave. Duration
- 4h 3m
- Frequency
- Twice daily
- Estimated price
- €30–65
- Website
- Trenitalia Intercity
Train from Lamezia Terme C. to Brindisi
- Ave. Duration
- 4h 3m
- Frequency
- Twice daily
- Estimated price
- €30–65
- Website
- Trenitalia Intercity
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 55m
- Frequency
- 4 times a day
- Estimated price
- €23–45
- Website
- Trenitalia Intercity
Train from Villa S.Giovanni to Amantea
- Ave. Duration
- 1h 23m
- Frequency
- Every 4 hours
- Estimated price
- €14–27
- Website
- Trenitalia Intercity
Train from Amantea to Brindisi
- Ave. Duration
- 3h 43m
- Frequency
- Twice daily
- Estimated price
- €30–60
- Website
- Trenitalia Intercity
- Phone
- 06 3000
- Website
- Trenitalia ICN
Night train from Palermo Centrale to Lamezia Terme C.
- Ave. Duration
- 6h 17m
- Frequency
- Twice daily
- Estimated price
- €30–50
- Website
- Trenitalia ICN
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 54m
- Frequency
- Hourly
- Estimated price
- €26–40
- Website
- Trenitalia
Train from Villa S.Giovanni to Amantea
- Ave. Duration
- 1h 33m
- Frequency
- Hourly
- Estimated price
- €16–23
- Website
- Trenitalia
- Phone
- +39 091-6208000
- [email protected]
- Website
- aziendasicilianatrasporti.it
Bus from Vicari to Palermo
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Schedules at
- aziendasicilianatrasporti.it
Bus from Vicari to Palermo
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Schedules at
- aziendasicilianatrasporti.it
Bus from Vicari to Palermo
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Schedules at
- aziendasicilianatrasporti.it
Bus from Vicari to Palermo
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Schedules at
- aziendasicilianatrasporti.it
Bus from Vicari to Palermo
- Ave. Duration
- 1h 35m
- Frequency
- Every 3 hours
- Schedules at
- aziendasicilianatrasporti.it
- Phone
- 800 21 10 20
- [email protected]
- Website
- SAIS Autolinee
Bus from Palermo Via Tommaso Fazello to Catania Central Bus Station
- Ave. Duration
- 2h 40m
- Frequency
- Every 3 hours
- Estimated price
- €11–17
- Schedules at
- SAIS Autolinee
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Palermo Via Tommaso Fazello to Catania Central Bus Station
- Ave. Duration
- 2h 35m
- Frequency
- 3 times a day
- Estimated price
- €17–27
- Website
- Flixbus
- Phone
- +39 0912742800
- [email protected]
- Website
- SAIS Transporti
Bus from Catania, Via D'Amico to Brindisi
- Ave. Duration
- 8h
- Frequency
- Twice daily
- Estimated price
- €35–50
- Website
- SAIS Transporti
- Phone
- +39 0362 185 0590
- [email protected]
- Website
- Onebus
Bus from Palermo Piazza Cairoli to Tarsia A3
- Ave. Duration
- 13h 15m
- Frequency
- Once a week
- Estimated price
- €150–210
- Website
- Onebus
- Phone
- +390981 500331
- [email protected]
- Website
- saj.it
Bus from Tarsia A3 to Brindisi
- Ave. Duration
- 4h
- Frequency
- 4 times a week
- Estimated price
- €19–35
- Schedules at
- saj.it
- Phone
- +39.06.5210550
- Website
- Trenitalia
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- Trenitalia
- Phone
- 090774409
- [email protected]
- Website
- bluferries.it
Car ferry from Tresmestieri to Villa S. Giovanni
- Ave. Duration
- 25 min
- Frequency
- Hourly
- Estimated price
- €19–35
- Schedules at
- bluferries.it
Want to know more about travelling around Italy
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Booking & Getting There
Palermo (Region) to Brindisi bus services, operated by Azienda Siciliana Trasporti, arrive at Palermo station.
Palermo (Region) to Brindisi train services, operated by Trenitalia Intercity, arrive at Lamezia Terme C. station.
There are 1001+ hotels available in Brindisi.

































