There are 9 ways to get from Palermo to Isernia by ferry, car, train, bus, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Ferry, drive
best- Take the ferry from Port of Palermo to Naples Beverelloferry
- Drive from Naples Beverello to Iserniacar
9h 58m€46–74Bus via Caserta
cheapest- Take the bus from Palermo Terminal Bus to Caserta pzza Garibaldibus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
12h 4m€37–54Train, ferry
- Take the train from Palermo Centrale to Messina Centraletrain Re
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Napoli Afragolatrain Fr
- Take the train from Napoli Afragola to Iserniatrain Re
11h 28mFly Palermo Airport to Naples Airport, train
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Caserta to Iserniatrain
6h 26m€47–159Ferry, train
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Take the train from Napoli Centrale to Iserniatrain Re
12h 1m€47–78Bus
- Take the bus from Palermo Piazza Cairoli to Casello - A1 Ingresso Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
17h 54mFly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 47m€52–153Bus to Trapani Airport, fly to Fiumicino International Airport, train
- Take the bus from Palermo Via Belgio/Via dei Nebrodi to Trapani Birgi Airportbus
- Fly from Trapani Airport (TPS) to Fiumicino International Airport (FCO)plane TPS - FCO
- Take the train from Roma Termini to Iserniatrain
7h 33m€68–206Bus to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminalbus
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Caserta to Iserniatrain
8h 22m€55–181
Palermo Airport (PMO) to Naples Airport (NAP) flights
Questions & Answers
The cheapest way to get from Palermo to Isernia is to bus via Caserta which costs €35 - €55 and takes 12h 4m.
The fastest way to get from Palermo to Isernia is to fly and train which takes 6h 26m and costs €45 - €160.
No, there is no direct bus from Palermo to Isernia. However, there are services departing from Palermo Terminal Bus and arriving at Isernia via Caserta Terminal Bus. The journey, including transfers, takes approximately 12h 4m.
The distance between Palermo and Isernia is 418 km.
The best way to get from Palermo to Isernia without a car is to train and ferry which takes 11h 28m and costs .
It takes approximately 9h 58m to get from Palermo to Isernia, including transfers.
Palermo to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Palermo Terminal Bus station.
Palermo to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta pzza Garibaldi station.
Book your Palermo to Isernia bus tickets online with Omio.
There are 478+ hotels available in Isernia.
What companies run services between Palermo, Italy and Isernia, Italy?
You can take a bus from Palermo Terminal Bus to Isernia via Caserta pzza Garibaldi and Caserta Terminal Bus in around 12h 4m.
- Website
- ryanair.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €30–140
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €26–95
Flights from Trapani Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €30–140
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €26–110
- Website
- ita-airways.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €40–100
Flights from Trapani Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €50–150
- Website
- easyjet.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h 1m
- When
- Every day
- Estimated price
- €28–130
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €27–130
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Friday and Sunday
- Estimated price
- €21–90
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- €40–100
- Website
- aeroitalia.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €22–300
- Website
- flexflight.dk
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €22–300
- Website
- flyulendo.com
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €17–55
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 3h 2m
- Frequency
- Every 2 hours
- Estimated price
- €27–45
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Afragola to Isernia
- Ave. Duration
- 1h 49m
- Frequency
- Every 4 hours
- Estimated price
- €14–24
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €16–27
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 16m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 16m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 3h
- Frequency
- 4 times a day
- Estimated price
- €23–50
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Napoli Afragola
- Ave. Duration
- 4h 4m
- Frequency
- Hourly
- Estimated price
- €60–130
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Villa S.Giovanni to Napoli Afragola
- Ave. Duration
- 4h 53m
- Frequency
- Twice daily
- Estimated price
- €50–110
- Website
- https://www.italotreno.it/en
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Terminal Bus to Caserta pzza Garibaldi
- Ave. Duration
- 9h 50m
- Frequency
- Twice daily
- Estimated price
- €30–45
- Schedules at
- autoservizisalemi.it
Bus from Palermo Via Belgio/Via dei Nebrodi to Trapani Birgi Airport
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- €6–10
- Schedules at
- autoservizisalemi.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- https://www.flixbus.fr
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- €6–11
- Website
- https://www.flixbus.co.uk
Bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminal
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- €17–28
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0362 185 0590
- [email protected]
- Website
- onebus.it
Bus from Palermo Piazza Cairoli to Casello - A1 Ingresso Caianello
- Ave. Duration
- 15h 59m
- Frequency
- Twice a week
- Website
- https://onebus.it/
- Phone
- 0865.221788
- [email protected]
- Website
- satiautobus.com
Bus from Casello - A1 Ingresso Caianello to Isernia
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- €2–3
- Schedules at
- satiautobus.com
- Phone
- 800 21 10 20
- [email protected]
- Website
- saisautolinee.it
Bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminal
- Ave. Duration
- 2h 30m
- Frequency
- Every 3 hours
- Estimated price
- €11–17
- Schedules at
- saisautolinee.it
- Phone
- +39.081.496.444
- [email protected]
- Website
- grimaldi-lines.com
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 8h 30m
- Frequency
- 6 times a week
- Estimated price
- €30–50
- Website
- https://www.grimaldi-lines.com/en/
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 8h 30m
- Frequency
- 6 times a week
- Estimated price
- €30–50
- Website
- https://www.grimaldi-lines.com/en/
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- https://www.trenitalia.com/en.html
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