There are 6 ways to get from Palermo to Mesagne by plane, bus, train (Trenitalia), car, car ferry, train, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, bus
best- Fly from Palermo Airport (PMO) to Brindisi Airport (BDS)plane PMO - BDS
- Take the bus from Borgo Casale to Mesagnebus
5h 7m€55–137Train (Trenitalia)
- Take the train from Palermo Centrale to Lamezia Terme C.train Ic
- Take the train from Lamezia Terme C. to Tarantotrain Ic
- Take the train from Taranto to Mesagnetrain Re
11h 23m€67–139Bus
- Take the bus from Palermo to Brindisibus N595
13h 17m€60–96Drive, car ferry
- Drive from Palermo to Tresmestiericar
- Take the carferry from Tresmestieri to Villa S. Giovannicarferry
- Drive from Villa S. Giovanni to Mesagnecar
7h 53m€121–183Train, ferry (Trenitalia)
- Take the train from Palermo Centrale to Messina Centraletrain Re
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Amanteatrain Re
- Take the train from Amantea to Tarantotrain Ic
- Take the train from Taranto to Mesagnetrain Re
11h 45mBus via Tarsia
- Take the bus from Palermo Piazza Cairoli to Tarsia A3bus
- Take the bus from Tarsia A3 to Brindisibus
20h
Palermo to Mesagne by train (Trenitalia)
Questions & Answers
The cheapest way to get from Palermo to Mesagne is to bus which costs €55 - €100 and takes 13h 17m.
The fastest way to get from Palermo to Mesagne is to fly and bus which takes 5h 7m and costs €55 - €140.
No, there is no direct bus from Palermo to Mesagne. However, there are services departing from Palermo and arriving at Mesagne via Brindisi - Viale Togliatti and Brindisi Via Indipendenza. The journey, including transfers, takes approximately 13h 17m.
No, there is no direct train from Palermo to Mesagne. However, there are services departing from Palermo Centrale and arriving at Mesagne via Lamezia Terme C. and Taranto. The journey, including transfers, takes approximately 11h 23m.
The distance between Palermo and Mesagne is 552 km.
The best way to get from Palermo to Mesagne without a car is to train which takes 11h 23m and costs €65 - €140.
It takes approximately 5h 7m to get from Palermo to Mesagne, including transfers.
Palermo to Mesagne bus services, operated by FlixBus, depart from Palermo station.
Palermo to Mesagne train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Mesagne is to train which takes 11h 23m and costs €65 - €140. Alternatively, you can bus, which costs €55 - €100 and takes 13h 17m.
What companies run services between Palermo, Italy and Mesagne, Italy?
You can take a train from Palermo Centrale to Mesagne via Lamezia Terme C. and Taranto in around 11h 23m. Alternatively, FlixBus operates a bus from Palermo to Brindisi once daily. Tickets cost €55–95 and the journey takes 11h 45m.
- Website
- ryanair.com
Flights from Palermo Airport to Brindisi Airport
- Ave. Duration
- 1h 15m
- When
- Tuesday and Saturday
- Estimated price
- €45–120
Flights from Palermo Airport to Brindisi Airport via Rome
- Ave. Duration
- 3h 30m
- When
- Wednesday
- Estimated price
- €45–120
- Website
- ita-airways.com
Flights from Palermo Airport to Brindisi Airport via Rome
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €90–130
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Palermo Centrale to Lamezia Terme C.
- Ave. Duration
- 5h 44m
- Frequency
- Twice daily
- Estimated price
- €35–75
- Website
- Trenitalia Intercity
Train from Lamezia Terme C. to Taranto
- Ave. Duration
- 2h 49m
- Frequency
- Twice daily
- Estimated price
- €26–55
- Website
- Trenitalia Intercity
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- €23–50
- Website
- Trenitalia Intercity
Train from Villa S.Giovanni to Amantea
- Ave. Duration
- 1h 22m
- Frequency
- 5 times a day
- Estimated price
- €14–30
- Website
- Trenitalia Intercity
Train from Amantea to Taranto
- Ave. Duration
- 2h 29m
- Frequency
- Twice daily
- Estimated price
- €23–50
- Website
- Trenitalia Intercity
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Taranto to Mesagne
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- €6–11
- Website
- Trenitalia
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 54m
- Frequency
- Every 4 hours
- Estimated price
- €27–45
- Website
- Trenitalia
Train from Villa S.Giovanni to Amantea
- Ave. Duration
- 1h 33m
- Frequency
- Every 3 hours
- Estimated price
- €17–28
- Website
- Trenitalia
Train from Taranto to Mesagne
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- €6–11
- Website
- Trenitalia
- Phone
- 800232042, 3667880781
- Website
- stpbrindisi.it
Bus from Borgo Casale to Mesagne
- Ave. Duration
- 35 min
- Frequency
- Every 3 hours
- Estimated price
- €1
- Schedules at
- stpbrindisi.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Palermo to Brindisi
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- €55–95
- Website
- Flixbus
- Phone
- +39 0362 185 0590
- [email protected]
- Website
- Onebus
Bus from Palermo Piazza Cairoli to Tarsia A3
- Ave. Duration
- 13h 15m
- Frequency
- Once a week
- Website
- Onebus
- Phone
- +390981 500331
- [email protected]
- Website
- saj.it
Bus from Tarsia A3 to Brindisi
- Ave. Duration
- 4h
- Frequency
- 4 times a week
- Estimated price
- €19–40
- Schedules at
- saj.it
- Phone
- 090774409
- [email protected]
- Website
- bluferries.it
Car ferry from Tresmestieri to Villa S. Giovanni
- Ave. Duration
- 25 min
- Frequency
- Hourly
- Estimated price
- €19–35
- Schedules at
- bluferries.it
- Phone
- +39.06.5210550
- Website
- Trenitalia
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- Trenitalia
Want to know more about travelling around Italy
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More Questions & Answers
Palermo to Mesagne bus services, operated by FlixBus, arrive at Brindisi station.
Palermo to Mesagne train services, operated by Trenitalia Intercity, arrive at Lamezia Terme C. station.
Book your Palermo to Mesagne train tickets online with Omio.
There are 1846+ hotels available in Mesagne.

























