There are 8 ways to get from Palermo to San Sebastián de los Reyes by plane, train (Trenitalia, Renfe, Ouigo), car ferry, train, bus, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Palermo Airport
best- Fly from Palermo Airport (PMO) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane PMO - MAD
6h 19m€56–240Train
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Milano Centraletrain
- Take the train from Milano Centrale to Lyon Part Dieutrain Fr
- Take the train from Lyon Part Dieu to Barcelona-Santstrain
- Take the train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandestrain Ave
30h 1m€333–627Car ferry, train
- Take the carferry from Port of Palermo to Port of Genoacarferry
- Take the train from Genova P.Za Principe to Ventimigliatrain Re
- Take the train from Nice-Ville to Marseille-Saint-Charlestrain
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandestrain
36h 57m€323–478Bus
- Take the bus from Palermo to Milano, Autostazione Lampugnanobus N597
- Take the bus from Milan to Madridbus FlixBus N1138
47h 50m€288–440Bus to Trapani Airport, fly
- Take the bus from Palermo Via Belgio/Via dei Nebrodi to Trapani Birgi Airportbus
- Fly from Trapani Airport (TPS) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane TPS - MAD
9h 10m€109–494Bus to Catania–Fontanarossa Airport, fly
- Take the bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminalbus
- Fly from Catania–Fontanarossa Airport (CTA) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane CTA - MAD
8h 25m€64–232Ferry, car ferry, train
- Take the ferry from Palermo to Civitavecchiaferry
- Take the carferry from Port of Civitavecchia to Port de Barcelonacarferry
- Take the train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandestrain Ave
38h 29m€196–394Bus, train
- Take the bus from Palermo Piazza Cairoli to Verona Porta Nuova Stationbus
- Take the train from Verona Porta Nuova to Padovatrain Fr
- Take the bus from Padova to Méndez Álvaro Estación Surbus
2d 6h€340–467
Palermo to San Sebastián de los Reyes by bus
Comparing Your Travel Options
The cheapest way to get from Palermo to San Sebastián de los Reyes is to bus and fly which costs €100 - €500 and takes 9h 10m.
The fastest way to get from Palermo to San Sebastián de los Reyes is to fly which takes 6h 19m and costs €55 - €240.
No, there is no direct bus from Palermo to San Sebastián de los Reyes. However, there are services departing from Palermo and arriving at Pºeuropa-Av.Montes De Oca via Milan, Méndez Álvaro, Cuatro Caminos and Intercambiador De Plaza Castilla. The journey, including transfers, takes approximately 47h 50m.
No, there is no direct train from Palermo to San Sebastián de los Reyes. However, there are services departing from Palermo Centrale and arriving at Alcobendas-San Sebastián de los Reyes via Roma Termini, Milano Centrale, Lyon Part Dieu, Barcelona-Sants and Madrid-Atocha Cercanías. The journey, including transfers, takes approximately 30h 1m.
The distance between Palermo and San Sebastián de los Reyes is 1513 km.
The best way to get from Palermo to San Sebastián de los Reyes without a car is to train which takes 30h 1m and costs €330 - €650.
It takes approximately 6h 19m to get from Palermo to San Sebastián de los Reyes, including transfers.
Palermo to San Sebastián de los Reyes bus services, operated by FlixBus, depart from Palermo station.
Palermo to San Sebastián de los Reyes train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to San Sebastián de los Reyes is to fly which takes 6h 19m and costs €55 - €240. Alternatively, you can train, which costs €330 - €650 and takes 30h 1m, you could also bus, which costs €280 - €440 and takes 47h 50m.
What companies run services between Palermo, Italy and San Sebastián de los Reyes, Spain?
Ryanair, Iberia, and Vueling Airlines fly from Palermo Airport (PMO) to Adolfo Suárez Madrid–Barajas Airport (MAD) twice daily. Alternatively, you can take a train from Palermo Centrale to Alcobendas-San Sebastián de los Reyes via Roma Termini, Milano Centrale, Lyon Part Dieu, Barcelona-Sants, Madrid-Puerta De Atocha-Almudena Grandes, and Madrid-Atocha Cercanías in around 30h 1m.
- Website
- ryanair.com
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 2h 40m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €50–190
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Turin
- Ave. Duration
- 4h 50m
- When
- Saturday
- Estimated price
- €100–410
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Milan Bergamo
- Ave. Duration
- 5h 15m
- When
- Saturday
- Estimated price
- €100–420
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Rome
- Ave. Duration
- 6h 15m
- When
- Friday
- Estimated price
- €95–400
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Bologna
- Ave. Duration
- 8h 40m
- When
- Sunday
- Estimated price
- €100–420
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Pisa
- Ave. Duration
- 10h 35m
- When
- Sunday
- Estimated price
- €100–410
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 3h
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €45–150
- Website
- iberia.com
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 2h 40m
- When
- Saturday
- Estimated price
- €70–360
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 4h 48m
- When
- Monday, Wednesday, Thursday, Friday, Sunday, and Saturday
- Estimated price
- €70–250
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 3h 5m
- When
- Saturday
- Estimated price
- €55–140
- Website
- vueling.com
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 4h 48m
- When
- Monday, Wednesday, Thursday, Friday, Sunday, and Saturday
- Estimated price
- €70–250
- Website
- aireuropa.com
Flights from Trapani Airport to Adolfo Suárez Madrid–Barajas Airport via Sevilla
- Ave. Duration
- 4h 50m
- When
- Sunday
- Estimated price
- €100–420
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 19m
- Frequency
- 4 times a day
- Estimated price
- €95–170
- Website
- Trenitalia Intercity
Train from Genova P.Za Principe to Ventimiglia
- Ave. Duration
- 2h 6m
- Frequency
- Hourly
- Estimated price
- €15–28
- Website
- Trenitalia Intercity
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €65–110
- Website
- Italo Treno
Train from Verona Porta Nuova to Padova
- Ave. Duration
- 43 min
- Frequency
- Hourly
- Estimated price
- €9–16
- Website
- Italo Treno
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Milano Centrale to Lyon Part Dieu
- Ave. Duration
- 4h 43m
- Frequency
- 4 times a day
- Estimated price
- €50–75
- Website
- Trenitalia
Train from Genova P.Za Principe to Ventimiglia
- Ave. Duration
- 2h 19m
- Frequency
- Hourly
- Estimated price
- €16–23
- Website
- Trenitalia
Train from Verona Porta Nuova to Padova
- Ave. Duration
- 1h 27m
- Frequency
- Every 20 minutes
- Estimated price
- €9–14
- Website
- Trenitalia
Rome2Rio's guide to Renfe Viajeros
Contact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe Viajeros
Train from Lyon Part Dieu to Barcelona-Sants
- Ave. Duration
- 4h 48m
- Frequency
- Twice daily
- Estimated price
- €80–120
- Website
- Renfe Viajeros
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 28m
- Frequency
- 4 times a day
- Estimated price
- €75–110
- Website
- Renfe Viajeros
Train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 8h 14m
- Frequency
- Twice daily
- Estimated price
- €140–210
- Website
- Renfe Viajeros
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 28m
- Frequency
- 4 times a day
- Estimated price
- €75–110
- Website
- Renfe Viajeros
Rome2Rio's guide to Renfe AVE
Contact Details
- Phone
- +34 91 232 03 20
- Website
- Renfe AVE
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 2m
- Frequency
- Every 30 minutes
- Estimated price
- €80–150
- Website
- Renfe AVE
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 2m
- Frequency
- Every 30 minutes
- Estimated price
- €80–150
- Website
- Renfe AVE
- Phone
- +34 900 926 851
- [email protected]
- Website
- Iryo
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 24m
- Frequency
- Hourly
- Estimated price
- €50–100
- Website
- Iryo
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 24m
- Frequency
- Hourly
- Estimated price
- €50–100
- Website
- Iryo
- Phone
- +34 900 759 781
- Website
- Ouigo
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 28m
- Frequency
- Hourly
- Estimated price
- €40–75
- Website
- Ouigo
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 28m
- Frequency
- Hourly
- Estimated price
- €40–75
- Website
- Ouigo
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Nice-Ville to Marseille-Saint-Charles
- Ave. Duration
- 2h 38m
- Frequency
- Hourly
- Estimated price
- €55–80
- Website
- Zou! Lignes Express Régionales
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Verona Porta Nuova to Padova
- Ave. Duration
- 44 min
- Frequency
- Every 30 minutes
- Estimated price
- €11–19
- Website
- Trenitalia Frecce
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Palermo to Milano, Autostazione Lampugnano
- Ave. Duration
- 22h 20m
- Frequency
- Once daily
- Estimated price
- €140–220
- Website
- Flixbus
Bus from Milan to Madrid
- Ave. Duration
- 23h 5m
- Frequency
- Once daily
- Estimated price
- €140–220
- Website
- Flixbus
Bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminal
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- €18–28
- Website
- Flixbus
- Phone
- (+39) 0923 98.11.20
- Website
- Autoservizi Salemi Srl
Bus from Palermo Via Belgio/Via dei Nebrodi to Trapani Birgi Airport
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- €6–10
- Schedules at
- Autoservizi Salemi Srl
- Phone
- 800 21 10 20
- [email protected]
- Website
- SAIS Autolinee
Bus from Palermo Via Tommaso Fazello to Catania Fontanarossa Airport Departure Terminal
- Ave. Duration
- 2h 30m
- Frequency
- Every 3 hours
- Estimated price
- €11–17
- Schedules at
- SAIS Autolinee
- Phone
- +39 0362 185 0590
- [email protected]
- Website
- Onebus
Bus from Palermo Piazza Cairoli to Verona Porta Nuova Station
- Ave. Duration
- 23h 51m
- Frequency
- Once a week
- Estimated price
- €200–290
- Website
- Onebus
- Phone
- +4-0263-21.55.00
- Website
- tabitatour.ro
Bus from Padova to Méndez Álvaro Estación Sur
- Ave. Duration
- 27h 35m
- Frequency
- Once a week
- Estimated price
- €120–160
- Schedules at
- tabitatour.ro
- Phone
- +39 010 209 4591
- [email protected]
- Website
- Grandi Navi Veloci
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 19h 30m
- Frequency
- Once daily
- Estimated price
- €100–150
- Website
- Grandi Navi Veloci
Ferry from Palermo to Civitavecchia
- Ave. Duration
- 13h 45m
- Frequency
- 3 times a week
- Estimated price
- €45–85
- Website
- Grandi Navi Veloci
Car ferry from Port of Civitavecchia to Port de Barcelona
- Ave. Duration
- 19h 30m
- Frequency
- Once a week
- Estimated price
- €100–150
- Website
- Grandi Navi Veloci
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Booking & Getting There
Palermo to San Sebastián de los Reyes bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Palermo to San Sebastián de los Reyes train services, operated by Trenitalia Intercity, arrive at Roma Termini station.
Book your Palermo to San Sebastián de los Reyes train tickets online with Omio.
There are 7043+ hotels available in San Sebastián de los Reyes.











































