There are 5 ways to get from Palm Coast to Santee by bus, taxi, train, car, plane, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, taxi
best- Take the bus from Palm Coast Bus Stop to Jacksonvillebus
- Take the bus from Jacksonville to Walterboro, SCbus
- Take the taxi from Walterboro, SC to Santeetaxi
6h 48m$164–233Drive 301.4 mi
cheapest- Drive from Palm Coast to Santeecar 301.4 mi
4h 58m$55–80Bus, train, drive
- Take the bus from Palm Coast Bus Stop to Jacksonvillebus
- Take the train from Jacksonville to Charleston Amtrak Stationtrain
- Drive from Charleston Amtrak Station to Santeecar
8h 34m$125–237Taxi, fly, drive
- Take the taxi from Palm Coast to Daytona-Beach-Airport-DABtaxi
- Fly from Daytona Beach International Airport (DAB) to Columbia (CAE)plane DAB - CAE
- Drive from Columbia-Airport-CAE to Santeecar
4h 58m$293–1,303Bus
- Take the bus from Palm Coast Bus Stop to Jacksonvillebus FlixBus 2431
- Take the bus from Jacksonville to Orangeburgbus FlixBus 2433
7h 21m$149–223
Daytona Beach International Airport (DAB) to Columbia (CAE) flights
Questions & Answers
The cheapest way to get from Palm Coast to Santee is to drive which costs $55 - $80 and takes 4h 58m.
The fastest way to get from Palm Coast to Santee is to taxi and fly and drive which takes 4h 58m and costs $290 - $1,300.
No, there is no direct bus from Palm Coast to Santee. However, there are services departing from Palm Coast Bus Stop and arriving at Orangeburg via Jacksonville. The journey, including transfers, takes approximately 7h 21m.
The distance between Palm Coast and Santee is 326 miles. The road distance is 303.2 miles.
The best way to get from Palm Coast to Santee without a car is to bus and taxi which takes 6h 48m and costs $160 - $240.
It takes approximately 6h 48m to get from Palm Coast to Santee, including transfers.
Palm Coast to Santee bus services, operated by Flixbus USA, depart from Palm Coast Bus Stop station.
Palm Coast to Santee bus services, operated by Flixbus USA, arrive at Jacksonville station.
Yes, the driving distance between Palm Coast to Santee is 303 miles. It takes approximately 4h 58m to drive from Palm Coast to Santee.
There are 41+ hotels available in Santee.
What companies run services between Palm Coast, FL, USA and Santee, SC, USA?
You can take a vehicle from Palm Coast to Santee via Palm Coast Bus Stop, Jacksonville, and Orangeburg in around 7h 21m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Jacksonville to Charleston Amtrak Station
- Ave. Duration
- 4h 14m
- Frequency
- Once daily
- Estimated price
- $80–170
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Jacksonville to Orangeburg
- Ave. Duration
- 4h 25m
- Frequency
- Once daily
- Estimated price
- $40–70
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
Bus from Jacksonville to Walterboro, SC
- Ave. Duration
- 3h 49m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
Bus from Palm Coast Bus Stop to Jacksonville
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $10–20
- Website
- https://www.greyhound.com/
Bus from Jacksonville to Orangeburg
- Ave. Duration
- 4h 40m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
- Ave. Duration
- 35 min
- Estimated price
- $70–120
Alliance Taxi and Shuttle
- Phone
- +1-386-259-3111
- Website
- alliancetaxiflagler.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide






