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How to get fromPalm Desert to Knoxvilleby plane, bus (Greyhound), bus, train, or car

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There are 6 ways to get from Palm Desert to Knoxville by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS)plane plane PSP - TYS
    6h 31m
    $362–1,226

  2. Bus

    1. Take the bus from Indio Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus
    3d 5h
    $614–1,114

  3. Bus, train

    1. Take the bus from Palm Desert Amtrak Bus Stop to Fullerton Amtrak Stationbus bus
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 6h
    $1,058–2,052

  4. Drive 2,061.6 mi

    1. Drive from Palm Desert to Knoxvillecar car 2,061.6 mi
    32h 52m
    $377–544

  5. Bus, train via San Bernardino

    1. Take the bus from Indio, CA to San Bernardino, CAbus bus
    2. Take the train from San Bernardino to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 7h
    $1,206–2,396

  6. Bus, train #2

    1. Take the bus from Palm Desert Amtrak Bus Stop to Fullerton Amtrak Stationbus bus
    2. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus
    3d 9h
    $1,228–2,452

Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS) flights

Calendar34Weekly Planes
Duration6h 40mAverage Duration
Ticket$268Cheapest Price
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Questions & Answers

Map of how to get from Palm Desert to Knoxville.ExpandLaunch map view
  • Distance: 1,866 mi
  • Duration: 6h 31m

What companies run services between Palm Desert, CA, USA and Knoxville, TN, USA?

United Airlines, Southwest Airlines, and two other airlines fly from Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS) 5 times a day. Alternatively, you can take a bus from Hwy 111 at San Luis Rey to Knoxville via Hwy 111 & Golf Center Pkwy, Indio Bus Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 5h.

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