There are 5 ways to get from Palm Springs to Knoxville by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS)plane PSP - TYS
6h 18m$330–1,188Bus
- Take the bus from Indio Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus
- Take the bus from New York to Knoxvillebus
3d 7h$614–1,115Bus, train
- Take the bus from Palm Springs Amtrak Bus Stop to Fullerton Amtrak Stationbus
- Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the bus from New York, NY to Knoxville, TNbus
3d 8h$1,179–2,356Drive 2,073.1 mi
- Drive from Palm Springs to Knoxvillecar 2,073.1 mi
33h 3m$379–547Bus, train via Charlie Haun WB Aft Washington PK
- Take the bus from Palm Springs Amtrak Bus Stop to Fullerton Amtrak Stationbus
- Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to New York City Chinatownbus
- Take the bus from New York, NY to Knoxville, TNbus
3d 12h$990–1,928
Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Palm Springs to Knoxville is to drive which costs $370 - $550 and takes 33h 3m.
The fastest way to get from Palm Springs to Knoxville is to fly which takes 6h 18m and costs $330 - $1,200.
No, there is no direct bus from Palm Springs to Knoxville. However, there are services departing from N Palm Canyon at Chino and arriving at Knoxville via Town Center & Hahn, Indio Bus Station, St Louis Bus Station and New York. The journey, including transfers, takes approximately 3 days 7h.
The distance between Palm Springs and Knoxville is 1868 miles. The road distance is 2085.2 miles.
The best way to get from Palm Springs to Knoxville without a car is to bus which takes 3 days 7h and costs $600 - $1,200.
It takes approximately 6h 18m to get from Palm Springs to Knoxville, including transfers.
Palm Springs to Knoxville bus services, operated by Greyhound USA, depart from Indio Bus Station.
The best way to get from Palm Springs to Knoxville is to fly which takes 6h 18m and costs $330 - $1,200. Alternatively, you can bus, which costs $600 - $1,200 and takes 3 days 7h.
Palm Springs to Knoxville bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Knoxville is 3h ahead of Palm Springs. It is currently 1:12 AM in Palm Springs and 4:12 AM in Knoxville.
What companies run services between Palm Springs, CA, USA and Knoxville, TN, USA?
United Airlines, Southwest Airlines, and two other airlines fly from Palm Springs International Airport (PSP) to Mcghee Tyson Airport (TYS) 5 times a day. Alternatively, you can take a bus from N Palm Canyon at Chino to Knoxville via Town Center & Hahn, Hwy 111 & Golf Center Pkwy, Indio Bus Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 7h.
- Website
- united.com
Flights from Palm Springs International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $270–1,100
Flights from Palm Springs International Airport to Mcghee Tyson Airport via Houston
- Ave. Duration
- 6h 45m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $280–1,200
- Website
- aa.com
Flights from Palm Springs International Airport to Mcghee Tyson Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 3m
- When
- Every day
- Estimated price
- $260–1,100
- Website
- southwest.com
Flights from Palm Springs International Airport to Mcghee Tyson Airport via Denver
- Ave. Duration
- 6h 15m
- When
- Monday, Thursday, and Friday
- Estimated price
- $270–1,100
- Website
- delta.com
Flights from Palm Springs International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 6h 20m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $270–1,200
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Fullerton Amtrak Station to Chicago Union Station
- Ave. Duration
- 42h 47m
- Frequency
- Once daily
- Estimated price
- $700–1,500
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 20h 12m
- Frequency
- Once daily
- Estimated price
- $310–650
- Website
- https://www.amtrak.com/home.html
Train from Fullerton Amtrak Station to Chicago Union Station
- Ave. Duration
- 42h 47m
- Frequency
- Once daily
- Estimated price
- $700–1,500
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Indio Bus Station to St Louis Bus Station
- Ave. Duration
- 36h 35m
- Frequency
- Once daily
- Estimated price
- $270–550
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Port Authority Bus Terminal
- Ave. Duration
- 24h 50m
- Frequency
- 3 times a day
- Estimated price
- $160–310
- Website
- https://www.greyhound.com/
- Phone
- +1 646-630-7186
- [email protected]
- Website
- wandacoach.com
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- https://www.wandacoach.com
- Book at
- https://www.gotobus.com/wanda-travel/
- Adult One Way
- $95–140
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Palm Springs Amtrak Bus Stop to Fullerton Amtrak Station
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- https://www.amtrak.com/home.html
Bus from Palm Springs Amtrak Bus Stop to Fullerton Amtrak Station
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 615-939-8887
- [email protected]
- Website
- nytnbus.com
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- https://www.nytnbus.com
- Adult One-way
- $95–110
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- https://www.nytnbus.com
- Adult One-way
- $95–110
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Chicago Bus Station to New York City Chinatown
- Ave. Duration
- 20h 45m
- Frequency
- 6 times a week
- Estimated price
- $160–270
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Yes, the driving distance between Palm Springs to Knoxville is 2085 miles. It takes approximately 33h 3m to drive from Palm Springs to Knoxville.
There are 317+ hotels available in Knoxville.








