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How to get fromPalo Alto to San Diegoby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 7 ways to get from Palo Alto to San Diego by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Norman Y. Mineta San José International Airport

    best
    1. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    3h 3m
    $78–509

  2. Caltrain to San Francisco International Airport, fly

    cheapest
    1. Take the train from California Avenue Caltrain Northbound to Millbrae Caltrain Northboundtrain train
    2. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    3h 12m
    $74–248

  3. Bus (Greyhound)

    1. Take the bus from San Jose Diridon Station to San Diego Greyhound Bus Stopbus bus Greyhound US0831
    12h 46m
    $75–146

  4. Train (Amtrak)

    1. Take the train from San Jose to Los Angelestrain train Coast Starlight
    2. Take the train from Los Angeles to San Diegotrain train Pacific Surfliner
    16h 2m
    $175–371

  5. Drive 475.3 mi

    1. Drive from Palo Alto to San Diegocar car 475.3 mi
    8h 5m
    $87–126

  6. Train to Oakland International Airport, fly

    1. Take the train from Santa Clara Amtrak to Oakland Coliseum/Airport Amtraktrain train
    2. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    4h 47m
    $93–294

  7. Bus via San Ysidro

    1. Take the bus from San Jose - King Rd to San Ysidrobus bus San Jose
    13h 30m
    $94–140

Palo Alto to San Diego by train, bus, and tram (Greyhound)

Calendar14Weekly Services
Duration12h 46mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Palo Alto to San Diego.ExpandLaunch map view
  • Distance: 434.1 mi
  • Duration: 3h 3m

What companies run services between Palo Alto, CA, USA and San Diego, CA, USA?

Alaska Airlines, Inc., Southwest Airlines, and Delta fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN) hourly. Alternatively, Greyhound USA operates a bus from San Jose Diridon Station to San Diego Greyhound Bus Stop twice daily. Tickets cost $70–140 and the journey takes 11h 10m.

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