There are 7 ways to get from Palo Alto to Santa Ana by plane, bus, train (Amtrak), car, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Norman Y. Mineta San José International Airport
best- Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane SJC - SNA
3h 13m$227–844Line 22 bus, bus
cheapest- Take the bus from El Camino & Churchill to Tully & Kingbus 22
- Take the bus from San Jose, CA - Huong Lan Sandwich to Westminster, CA - ABC Supermarketbus San Jose
10h 5m$50–67Train (Amtrak)
- Take the train from San Jose to Los Angelestrain Coast Starlight
- Take the train from Los Angeles to Santa Anatrain Pacific Surfliner
13h 55m$113–287Drive 387.1 mi
- Drive from Palo Alto to Santa Anacar 387.1 mi
6h 33m$71–102Caltrain to San Francisco International Airport, fly
- Take the train from California Avenue Caltrain Northbound to Millbrae Caltrain Northboundtrain
- Fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA)plane SFO - SNA
3h 30m$143–383Train to Oakland International Airport, fly
- Take the train from Santa Clara Amtrak to Oakland Coliseum/Airport Amtraktrain
- Fly from Oakland International Airport (OAK) to John Wayne Airport Orange County (SNA)plane OAK - SNA
4h 56m$255–816Bus (Greyhound)
- Take the bus from San Jose Diridon Station to Santa Ana Bus Stopbus Greyhound US0831
10h 50m$65–106
Palo Alto to Santa Ana by bus
Comparing Your Travel Options
The cheapest way to get from Palo Alto to Santa Ana is to line 22 bus and bus which costs $45 - $70 and takes 10h 5m.
The fastest way to get from Palo Alto to Santa Ana is to fly which takes 3h 13m and costs $220 - $850.
No, there is no direct bus from Palo Alto to Santa Ana. However, there are services departing from El Camino & Churchill and arriving at 1St-Main via San Jose, CA - Huong Lan Sandwich and Bolsa-Magnolia. The journey, including transfers, takes approximately 10h 5m.
No, there is no direct train from Palo Alto to Santa Ana. However, there are services departing from California Avenue Caltrain Southbound and arriving at Santa Ana via San Jose and Los Angeles. The journey, including transfers, takes approximately 13h 55m.
The distance between Palo Alto and Santa Ana is 367 miles. The road distance is 389.4 miles.
The best way to get from Palo Alto to Santa Ana without a car is to line 22 bus and bus which takes 10h 5m and costs $45 - $70.
It takes approximately 3h 13m to get from Palo Alto to Santa Ana, including transfers.
Palo Alto to Santa Ana bus services, operated by Santa Clara VTA, depart from El Camino & Churchill station.
Palo Alto to Santa Ana train services, operated by Amtrak, depart from San Jose station.
The best way to get from Palo Alto to Santa Ana is to fly which takes 3h 13m and costs $220 - $850. Alternatively, you can line 22 bus and bus, which costs $45 - $70 and takes 10h 5m, you could also train, which costs $110 - $290 and takes 13h 55m.
What companies run services between Palo Alto, CA, USA and Santa Ana, CA, USA?
Southwest Airlines flies from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA) every 4 hours. Alternatively, you can take a bus from El Camino & Churchill to 1St-Main via Tully & King, San Jose, CA - Huong Lan Sandwich, Westminster, CA - ABC Supermarket, and Bolsa-Magnolia in around 10h 5m.
- Website
- southwest.com
Flights from Norman Y. Mineta San José International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $50–320
Flights from Norman Y. Mineta San José International Airport to John Wayne Airport Orange County via Las Vegas
- Ave. Duration
- 3h 35m
- When
- Monday, Thursday, and Friday
- Estimated price
- $65–370
Flights from Oakland International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $50–330
Flights from Oakland International Airport to John Wayne Airport Orange County via Las Vegas
- Ave. Duration
- 3h 43m
- When
- Saturday
- Estimated price
- $65–380
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from San Jose to Los Angeles
- Ave. Duration
- 10h 45m
- Frequency
- Once daily
- Estimated price
- $100–260
- Website
- Amtrak
Train from Los Angeles to Santa Ana
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $8–21
- Website
- Amtrak
Train from Santa Clara Amtrak to Oakland Coliseum/Airport Amtrak
- Ave. Duration
- 50 min
- Frequency
- Every 4 hours
- Estimated price
- $9–22
- Website
- Amtrak
- Phone
- +1 408-321-2300
- [email protected]
- Website
- Santa Clara VTA
Bus from El Camino & Churchill to Tully & King
- Ave. Duration
- 1h 53m
- Frequency
- Every 20 minutes
- Estimated price
- $2–5
- Website
- Santa Clara VTA
- Adult
- $2–5
Want to know more about travelling around United States
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Booking & Getting There
Palo Alto to Santa Ana bus services, operated by Santa Clara VTA, arrive at Tully & King station.
Palo Alto to Santa Ana train services, operated by Amtrak, arrive at Los Angeles station.
Yes, the driving distance between Palo Alto to Santa Ana is 389 miles. It takes approximately 6h 33m to drive from Palo Alto to Santa Ana.
There are 1605+ hotels available in Santa Ana.








