There are 7 ways to get from Panama City Beach to Antigua Guatemala by plane, bus (Greyhound), car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Northwest Florida Beaches International Airport
best- Fly from Northwest Florida Beaches International Airport (ECP) to La Aurora International Airport (GUA)plane ECP - GUA
8h 22m$187–665Drive to Destin–Fort Walton Beach Airport, fly
cheapest- Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car
- Fly from Destin–Fort Walton Beach Airport (VPS) to La Aurora International Airport (GUA)plane VPS - GUA
9h 54m$134–617Bus
- Take the bus from Panama City Beach Bus Station to Houston Bus Stationbus
- Take the bus from Houston - Harrisburg Blvd to McAllen Central Stationbus
- Take the bus from Reynosa to Coatzacoalcosbus
- Take the bus from Coatzacoalcos to San Cristóbal de las Casasbus
- Take the bus from San Cristóbal de las Casas to Antigua Guatemalabus
2d 8h$398–619Drive 3,444.4 km
- Drive from Panama City Beach to Antigua Guatemalacar 3,444.4 km
43h 47m$416–600Drive to Dothan Regional Airport, fly
- Drive from Panama City Beach to Dothan Regional Airport (DHN)car
- Fly from Dothan Regional Airport (DHN) to La Aurora International Airport (GUA)plane DHN - GUA
10h 31m$140–626Bus via Mexico City
- Take the bus from Panama City Beach Bus Station to Houston Bus Stationbus
- Take the bus from Houston Bus Station to San Antonio Bus Stationbus
- Take the bus from San Antonio to Terminal Central de Autobuses del Nortebus
- Take the bus from Politécnico to Comitánbus
- Take the bus from Comitán to Antigua Guatemalabus
2d 11h$370–608Bus #2
- Take the bus from Panama City Beach Bus Station to Houston Bus Stationbus Greyhound US0799
- Take the bus from Houston to Guatemala Citybus
3d 13h$293–606
Northwest Florida Beaches International Airport (ECP) to La Aurora International Airport (GUA) flights
Questions & Answers
The cheapest way to get from Panama City Beach to Antigua Guatemala is to drive and fly which costs $130 - $650 and takes 9h 54m.
The fastest way to get from Panama City Beach to Antigua Guatemala is to fly which takes 8h 22m and costs $180 - $700.
No, there is no direct bus from Panama City Beach station to Antigua Guatemala. However, there are services departing from Panama City Beach Bus Station and arriving at Antigua Guatemala via Houston - Harrisburg Blvd, McAllen Central Station, Reynosa, Coatzacoalcos and San Cristóbal de las Casas. The journey, including transfers, takes approximately 2 days 8h.
The distance between Panama City Beach and Antigua Guatemala is 1889 km. The road distance is 3444.4 km.
The best way to get from Panama City Beach to Antigua Guatemala without a car is to bus which takes 2 days 8h and costs $390 - $650.
It takes approximately 8h 22m to get from Panama City Beach to Antigua Guatemala, including transfers.
Panama City Beach to Antigua Guatemala bus services, operated by Greyhound USA, depart from Panama City Beach Bus Station.
The best way to get from Panama City Beach to Antigua Guatemala is to fly which takes 8h 22m and costs $180 - $700. Alternatively, you can bus, which costs $390 - $650 and takes 2 days 8h.
Panama City Beach to Antigua Guatemala bus services, operated by Greyhound USA, arrive at Houston Bus Station.
Antigua Guatemala is 1h behind Panama City Beach. It is currently 9:26 PM in Panama City Beach and 8:26 PM in Antigua Guatemala.
What companies run services between Panama City Beach, FL, USA and Antigua Guatemala?
United Airlines, Delta, and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to La Aurora International Airport (GUA) every 4 hours. Alternatively, you can take a vehicle from Panama City Beach to Antigua Guatemala via Panama City Beach Bus Station, Houston Bus Station, Houston - Harrisburg Blvd, McAllen Central Station, Reynosa, Coatzacoalcos, San Cristóbal de las Casas, and San Cristóbal de las Casas in around 2d 8h.
- Website
- united.com
Flights from Northwest Florida Beaches International Airport to La Aurora International Airport via Houston
- Ave. Duration
- 7h 46m
- When
- Every day
- Estimated price
- $120–550
- Website
- aa.com
Flights from Northwest Florida Beaches International Airport to La Aurora International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 50m
- When
- Every day
- Estimated price
- $140–650
Flights from Destin–Fort Walton Beach Airport to La Aurora International Airport via Miami
- Ave. Duration
- 10h 6m
- When
- Every day
- Estimated price
- $110–550
Flights from Destin–Fort Walton Beach Airport to La Aurora International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 31m
- When
- Every day
- Estimated price
- $140–600
- Website
- delta.com
Flights from Northwest Florida Beaches International Airport to La Aurora International Airport via Atlanta
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $120–550
Flights from Destin–Fort Walton Beach Airport to La Aurora International Airport via Atlanta
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $120–550
Flights from Dothan Regional Airport to La Aurora International Airport via Atlanta
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $110–550
- Website
- avianca.com
Flights from Destin–Fort Walton Beach Airport to La Aurora International Airport via Chicago O'Hare
- Ave. Duration
- 8h 36m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- $320–1,100
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Panama City Beach Bus Station to Houston Bus Station
- Ave. Duration
- 13h 40m
- Frequency
- Once daily
- Estimated price
- $90–180
- Website
- Greyhound
Bus from Panama City Beach Bus Station to Houston Bus Station
- Ave. Duration
- 13h 40m
- Frequency
- Once daily
- Estimated price
- $90–180
- Website
- Greyhound
Bus from Houston Bus Station to San Antonio Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- 4 times a day
- Estimated price
- $29–60
- Website
- Greyhound
Bus from Panama City Beach Bus Station to Houston Bus Station
- Ave. Duration
- 13h 40m
- Frequency
- Once daily
- Estimated price
- $90–180
- Website
- Greyhound
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Houston - Harrisburg Blvd to McAllen Central Station
- Ave. Duration
- 7h
- Frequency
- Once daily
- Estimated price
- $75–95
- Schedules at
- Omnibus Express
- Phone
- +52 55 4386 4652
- [email protected]
- Website
- ado.com.mx
Bus from Reynosa to Coatzacoalcos
- Ave. Duration
- 18h 59m
- Frequency
- 4 times a day
- Estimated price
- $140–210
- Schedules at
- ado.com.mx
- Book at
- ado.com.mx
Bus from Coatzacoalcos to San Cristóbal de las Casas
- Ave. Duration
- 4h 51m
- Frequency
- Twice daily
- Estimated price
- $35–55
- Schedules at
- ado.com.mx
- Book at
- ado.com.mx
- Phone
- +52 55 4386 4652
- [email protected]
- Website
- ado.com.mx
Bus from Coatzacoalcos to San Cristóbal de las Casas
- Ave. Duration
- 5h 41m
- Frequency
- Every 3 hours
- Estimated price
- $30–70
- Schedules at
- ado.com.mx
- Book at
- ado.com.mx
- Phone
- +502 7762 2462
- [email protected]
- Website
- Eterna Primavera
Bus from San Cristóbal de las Casas to Antigua Guatemala
- Ave. Duration
- 5h 30m
- Frequency
- 5 times a day
- Estimated price
- $53
- Website
- Eterna Primavera
Bus from Comitán to Antigua Guatemala
- Ave. Duration
- 4h
- Frequency
- 5 times a week
- Estimated price
- $53
- Website
- Eterna Primavera
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Houston Bus Station to San Antonio Bus Station
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
- Phone
- +1 800 923 1799
- [email protected]
- Website
- Omnibus Express (OMEX VIP)
Bus from San Antonio to Terminal Central de Autobuses del Norte
- Ave. Duration
- 20h 3m
- Frequency
- Once daily
- Estimated price
- $140–230
- Schedules at
- Omnibus Express (OMEX VIP)
- Phone
- +52 961 638 5018
- [email protected]
- Website
- autobusestitanium.com
Bus from Politécnico to Comitán
- Ave. Duration
- 14h 30m
- Frequency
- Once daily
- Estimated price
- $45–70
- Schedules at
- autobusestitanium.com
- Book at
- autobusestitanium.com
- Delux
- $50–70
- First Class
- $45–55
- Phone
- +1 213 368 1172
- [email protected]
- Website
- busesusatours.com
Bus from Houston to Guatemala City
- Ave. Duration
- 2d 17h
- Frequency
- Once a week
- Estimated price
- $170–390
- Schedules at
- busesusatours.com
Want to know more about travelling around Guatemala
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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More Questions & Answers
Yes, the driving distance between Panama City Beach to Antigua Guatemala is 3444 km. It takes approximately 43h 47m to drive from Panama City Beach to Antigua Guatemala.
There are 821+ hotels available in Antigua Guatemala.



























