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How to get fromPanama City Beach to Cape Girardeauby plane, bus, bus (Greyhound, Flixbus), train, taxi, or car

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There are 8 ways to get from Panama City Beach to Cape Girardeau by plane, bus, bus (Greyhound, Flixbus), train, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Lambert–St. Louis International Airport, bus

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 4m
    $181–661

  2. Drive 615.3 mi

    cheapest
    1. Drive from Panama City Beach to Cape Girardeaucar car 615.3 mi
    12h 19m
    $113–163

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    3. Take the bus from New Orleans Bus Station to Cape Girardeaubus bus
    21h 19m
    $146–275

  4. Bus, train, taxi

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    4. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    25h 38m
    $353–686

  5. Drive to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport, bus

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 6m
    $133–613

  6. Bus to Pensacola International Airport, fly to Cape Girardeau Municipal Airport

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Cape Girardeau Municipal Airport (CGI)plane plane PNS - CGI
    5h 42m
    $167–527

  7. Drive to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport, bus

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 27m
    $126–452

  8. Bus to Pensacola International Airport, fly to Lambert–St. Louis International Airport, bus

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    9h 22m
    $131–536

Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL) flights

Calendar29Weekly Planes
Duration2h 53mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Cape Girardeau.ExpandLaunch map view
  • Distance: 783 mi
  • Duration: 6h 4m

What companies run services between Panama City Beach, FL, USA and Cape Girardeau, MO, USA?

You can take a vehicle from Panama City Beach to Cape Girardeau via Panama City Beach Bus Station, Mobile Bus Station, New Orleans Bus Station, and Cape Girardeau in around 21h 19m.

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