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How to get fromPanama City Beach to Charlestonby plane, bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Panama City Beach to Charleston by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Charleston International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Charleston International Airport (CHS)plane plane ECP - CHS
    5h 19m
    $121–446

  2. Drive to Destin–Fort Walton Beach Airport, fly to Charleston International Airport

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS)plane plane VPS - CHS
    6h 43m
    $78–398

  3. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    13h 18m
    $155–304

  4. Drive 447.2 mi

    1. Drive from Panama City Beach to Charlestoncar car 447.2 mi
    9h 4m
    $82–118

  5. Fly Northwest Florida Beaches International Airport to Hilton Head Airport, drive

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Hilton Head Airport (HHH)plane plane ECP - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 16m
    $127–441

  6. Drive to Dothan Regional Airport, fly to Charleston International Airport

    1. Drive from Panama City Beach to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Charleston International Airport (CHS)plane plane DHN - CHS
    6h 49m
    $79–387

  7. Bus (Greyhound)

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Sumter Bus Stopbus bus
    3. Take the bus from Sumter Bus Stop to Charleston Bus Stationbus bus
    20h 29m
    $123–235

Northwest Florida Beaches International Airport (ECP) to Charleston International Airport (CHS) flights

Calendar62Weekly Planes
Duration4h 47mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Charleston.ExpandLaunch map view
  • Distance: 414.1 mi
  • Duration: 5h 19m

What companies run services between Panama City Beach, FL, USA and Charleston, SC, USA?

Delta, American Airlines, and Southwest Airlines fly from Northwest Florida Beaches International Airport (ECP) to Charleston International Airport (CHS) every 3 hours. Alternatively, you can take a vehicle from Panama City Beach to Transit Mall via Panama City Beach Bus Station, Jacksonville, Sumter Bus Stop, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 20h 29m.

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