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How to get fromPanama City Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 9 ways to get from Panama City Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Chicago Midway International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Chicago Midway International Airport (MDW)plane plane ECP - MDW
    3h 19m
    $131–459

  2. Drive to Destin–Fort Walton Beach Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Chicago O'Hare International Airport (ORD)plane plane VPS - ORD
    4h 54m
    $78–351

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    24h 16m
    $176–346

  4. Bus, train via New Orleans

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    3. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train
    28h 4m
    $357–756

  5. Drive 888.4 mi

    1. Drive from Panama City Beach to Chicagocar car 888.4 mi
    16h 44m
    $163–235

  6. Fly Northwest Florida Beaches International Airport to Chicago O'Hare International Airport

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Chicago O'Hare International Airport (ORD)plane plane ECP - ORD
    3h 55m
    $121–399

  7. Drive to Destin–Fort Walton Beach Airport, fly to Chicago Midway International Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Chicago Midway International Airport (MDW)plane plane VPS - MDW
    4h 27m
    $88–401

  8. Bus via Atlanta

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    25h 1m
    $181–356

  9. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus Greyhound US0760S
    2. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    43h 52m
    $551–1,194

Northwest Florida Beaches International Airport (ECP) to Chicago Midway International Airport (MDW) flights

Calendar35Weekly Planes
Duration3h 52mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Chicago.ExpandLaunch map view
  • Distance: 826.8 mi
  • Duration: 3h 19m

What companies run services between Panama City Beach, FL, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Northwest Florida Beaches International Airport (ECP) to Chicago Midway International Airport (MDW) 5 times a day. Alternatively, you can take a vehicle from Panama City Beach to Chicago Bus Station via Panama City Beach Bus Station, Tallahassee, and Nashville Bus Station in around 24h 16m.

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